grant
Homeostatic Mechanisms Regulating Mitochondrial Health
Organization CALIFORNIA INSTITUTE OF TECHNOLOGYLocation PASADENA, UNITED STATESPosted 1 Jul 2018Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025ActinsApoptosisApoptosis PathwayAstrocytesAstrocytusAstrogliaBiogenesisCNS Nervous SystemCRISPR interferenceCRISPR-dCas9-mediated repressionCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCalciumCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular MatrixCellular PhysiologyCellular ProcessCellular StressCellular Stress ResponseCellular biologyCentral Nervous SystemChromatin Remodeling ComplexChromatin Remodeling FactorCitric Acid CycleClustered Regularly Interspaced Short Palindromic Repeats interferenceCoupledCouplingCytoskeletal SystemCytoskeletonDataDiseaseDisorderEnsureEquilibriumEukaryotic CellEventFatty Acid Metabolism PathwayFe elementFutureGene ExpressionGenerationsGenesHealthHumanInnate ImmunityIntracellular Communication and SignalingIronKnowledgeKrebs CycleLinkLysosomesMembrane FusionMitochondriaModern ManMolecularNative ImmunityNatural ImmunityNerve CellsNerve UnitNeural CellNeuraxisNeurocyteNeuronsNon-Specific ImmunityNonspecific ImmunityOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellOrganellesOrigin of LifeOxidative PhosphorylationOxidative Phosphorylation PathwayPathway interactionsPhenotypePhysiologyPlayPopulationProcessProgrammed Cell DeathR-Series Research ProjectsR01 MechanismR01 ProgramResearchResearch GrantsResearch Project GrantsResearch ProjectsRoleS elementSignal TransductionSignal Transduction SystemsSignalingSubcellular ProcessSulfurTCA cycleTricarboxylic Acid Cycleastrocytic gliabalancebalance functionbiological adaptation to stressbiological signal transductioncell biologycell stresschromatin modifierdensityentire genomefatty acid metabolismfull genomeimprovedin vivoinsightintracellular skeletonmitochondrialmouse geneticsneuronalpathwayprogramspublic health relevancereaction; crisisrepressing CRISPR-dCas9 systemresponsesocial rolestress responsestress; reactionwhole genome
Description preview
Project Summary/Abstract
Mitochondria are best known as the “powerhouses” of the cell, due to their predominant role in generating
cellular energy through the tricarboxylic acid cycle, fatty acid metabolism, and oxidative phosphorylation
(OXPHOS). Beyond energy generation, these essential organelles also play central roles in apoptosis,
calcium…
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