grant
HIV persistence in vivo
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAffectBlood SampleBlood specimenCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCell BodyCell FunctionCell Growth in NumberCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCellsCellular FunctionCellular PhysiologyCellular ProcessCellular ProliferationChronicDetectionDevelopmentEmulsionsEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExpression SignatureFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGene Expression ProfileGenomic DNAGoalsHIVHIV InfectionsHTLV-III InfectionsHTLV-III-LAV InfectionsHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHydrogen OxideImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsIndividualInstitutionInterruptionLAV-HTLV-IIILymphadenopathy-Associated VirusMorbidityMorbidity - disease rateOilsParticipantPhenotypePopulationSortingSubcellular ProcessT-Cell SubsetsT-Lymphocyte SubsetsT4 CellsT4 LymphocytesTissue SampleVirusVirus ReplicationVirus-HIVWaterWorkantiretroviral therapyantiretroviral treatmentcell typedevelopmentalepigeneticallyflow cytophotometrygDNAgene expression patterngene expression signaturein vivointervention designmortalitynovelpreventpreventingproteomic signaturetherapy designtranscriptional profiletranscriptional signaturetranscriptomicstreatment designviral multiplicationviral replicationvirus multiplication
Description preview
The purpose of this project is to help elucidate how HIV persists in vivo and thus to aid the development of novel HIV cure-directed therapies. The focus of the work is a small population of CD4 T cells that contain replication-competent HIV and persist at nearly stable levels even in the setting of effective antiretroviral therapy (ART).…
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