grant
HIV Neutralization Inhibitors: Engineering, characterization, and functions
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVAIDS VirusAIDS/HIVAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAntigensBi-specific antibodiesBifunctional AntibodiesBinding SitesBiochemicalBispecific AntibodiesCOVID-19 virusCOVID19 virusCarbohydratesCoV-2CoV2Combining SiteCoronaviridaeCoronavirusCryo-electron MicroscopyCryoelectron MicroscopyD-MannoseDevelopmentDiseaseDisorderDrug resistanceElectron CryomicroscopyEngineeringEnvelope ProteinFinding natural productsFoundationsGlycansGlycoproteinsGoalsHCVHIVHIV Envelope Glycoprotein gp120HIV Envelope Protein gp120HIV env Protein gp120HIV-1HIV-IHIV/AIDSHIV1HTLV-III gp120Hepatitis C virusHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman immunodeficiency virus 1Immune systemIndividualInfectionLAV-HTLV-IIILife ExpectancyLocal MicrobicidesLymphadenopathy-Associated VirusMannan-Binding LectinMannan-Binding ProteinMannopyranoseMannopyranosideMannoseMannose Binding LectinMannose-Binding ProteinMannose-Specific LectinMediatingModern ManNMR SpectrometerNMR SpectroscopyNatural product discoveryOligosaccharidesOrthocoronavirinaePeptidesPolysaccharidesPreventative strategyPrevention strategyPreventive strategyProtein EngineeringProteinsPublicationsReactive SiteReceptor ProteinResearchSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Scientific PublicationSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2Single Crystal DiffractionSiteStructureTherapeuticTherapeutic UsesTranslatingTranslationsVaccine DesignVaccinesViralViral Gene ProductsViral Gene ProteinsViral GenomeViral ProteinsVirusVirus-HIVWorkWuhan coronavirusX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray CrystallographybsAbcarbohydrate binding proteincarbohydrate receptorchimeric antibodycorona viruscoronavirus disease 2019 viruscoronavirus disease-19 viruscostcryo-EMcryoEMcryogenic electron microscopydesigndesign and constructdesign and constructiondesigningdevelop a vaccinedevelop drug resistancedevelop vaccinesdevelopment of a vaccinedevelopmentaldrug resistance developmentdrug resistantenv Antigensenv Gene Productsenv Polyproteinsenv Proteingenetic protein engineeringgp120gp120 ENV Glycoproteingp120(HIV)hCoV19immunogenin vivoinhibitornCoV2novelnuclear magnetic resonance spectroscopyprotein bound carbohydrateprotein designreceptorreceptor bindingreceptor boundresistance to Drugresistant to Drugsmall molecular inhibitorsmall moleculesmall molecule inhibitorsmall molecule therapeuticstopical delivered microbicidetopical microbicidetranslationvaccine developmentvirus envelopevirus genomevirus protein
Description preview
The long-term goals of our project "HIV Neutralization Inhibitors: Engineering, characterization, and functions" are to identify and engineer protein and small molecule therapeutics, probes and vaccine immunogens that can be translated for the treatment and long-acting inhibition of HIV/AIDS. Though great progress has been achieved in developing…
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