grant
HIV-1 membrane fusion and inhibition
Organization BOSTON CHILDREN'S HOSPITALLocation BOSTON, UNITED STATESPosted 20 May 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoV2019-nCoV S protein2019-nCoV spike glycoprotein2019-nCoV spike proteinAddressAntibodiesBindingBinding SitesC-C CKR-5C-C CKR-5 GeneC-C Chemokine Receptor Type 5C-C Chemokine Receptor Type 5 GeneCC Chemokine Receptor 5CC-CKR-5CC-CKR-5 GeneCC-CKR5CCCKR5CCCKR5 GeneCCR-5CCR-5 GeneCCR5CCR5 ProteinCCR5 ReceptorsCCR5 geneCD195 AntigenCD195 Antigen GeneCD4 AntigensCD4 MoleculeCD4 ProteinCD4 ReceptorsCHEMR13CHEMR13 GeneCKR-5CKR-5 GeneCKR5CKR5 GeneCKR5 ReceptorsCMKBR5CMKBR5 GeneCOVID-19 S proteinCOVID-19 spikeCOVID-19 spike glycoproteinCOVID-19 spike proteinCOVID-19 virusCOVID19 virusCXC-R4CXCR-4CXCR4CXCR4 geneCell BodyCell surfaceCellsChemokine (C-C Motif) Receptor 5Chemokine (C-C) Receptor 5Chemokine (C-C) Receptor 5 GeneChemokine Receptor GeneClinical Treatment MoabCoV-2CoV2Combining SiteComplexCryo-electron MicroscopyCryo-electron tomographyCryoelectron MicroscopyCytoplasmic DomainCytoplasmic TailD2S201EDetergentsDevelopmentEbolaElectron CryomicroscopyElectron MicroscopyEnvelope ProteinFB22FDA approvedFutureGlycoproteinsGoalsHIV Envelope Glycoprotein gp120HIV Envelope Protein gp120HIV env Protein gp120HIV-1HIV-1 Fusion Co-ReceptorHIV-1 Fusion Co-Receptor GeneHIV-IHIV1HM89HSY3RRHTLV-III gp120HumanHuman Immunodeficiency Virus Type 1Human immunodeficiency virus 1InfectionInfection preventionInfluenza HAInfluenza HemagglutininIntervention StrategiesLAP3LCR1LESTRLengthLipid BilayersLipidsMediatingMembraneMembrane FusionMetabolic GlycosylationMicellesModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular Mechanisms of ActionMolecular StereochemistryMonoclonal AntibodiesNPY3RNPYRNPYRLNPYY3ROKT4 antigenPilot ProjectsPrevent infectionProcessPropertyReactionReactive SiteReceptor ProteinResolutionRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 SSARS-CoV-2 S proteinSARS-CoV-2 spikeSARS-CoV-2 spike glycoproteinSARS-CoV-2 spike proteinSARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SeriesSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 S proteinSevere acute respiratory syndrome coronavirus 2 spike glycoproteinSevere acute respiratory syndrome coronavirus 2 spike proteinSevere acute respiratory syndrome related corona virus 2StructureSurfaceSurface CD4 ReceptorsSystemT4 moleculeTM DomainTechnologyTherapeuticTherapeutic AgentsTransmembrane DomainTransmembrane RegionViralViral Fusion ProteinsViral VaccinesVirionVirusVirus InhibitorsVirus ParticleVisualizationWuhan coronaviruschemokine receptorconformationconformationalconformational stateconformationallyconformationscoronavirus disease 2019 S proteincoronavirus disease 2019 spike glycoproteincoronavirus disease 2019 spike proteincoronavirus disease 2019 viruscoronavirus disease-19 viruscryo-EMcryo-EM tomographycryoEMcryoEM tomographycryoelectron tomographycryogenic electron microscopydesigndesigningdevelop a vaccinedevelop therapydevelop vaccinesdevelopment of a vaccinedevelopmentalelectron cryo-tomographyelectron tomographyenv Antigensenv Gene Productsenv Polyproteinsenv Proteinflu HAflu hemagglutininglycosylationgp120gp120 ENV Glycoproteingp120(HIV)gp160hCoV19helper T lymphocyte markerimprovedinfluenza viral HAinfluenza viral hemagglutinininfluenza virus HAinfluenza virus hemagglutinininhibitorinsightintervention developmentlipid bilayer membranemAbsmembrane assemblymembrane structuremonoclonal AbsmovienCoV2nanodiskneutralizing antibodynovelparticlepilot studyreceptorreceptor bindingreceptor boundreconstitutereconstitutionresolutionssmall moleculesocial rolespike proteins on SARS-CoV-2structural biologytherapy developmenttreatment developmentvaccine developmentviral inhibitor
Description preview
Summary
Virus entry begins with the first encounter between the virus and the cell surface and ends with delivery of the
contents of the virus into the host cell. HIV-1 membrane fusion is the first key delivery step, mediated by the
virus-encoded envelope glycoprotein [Env; trimeric (gp160)3 cleaved to (gp120/gp41)3], which belongs to the
group of…
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