grant
Hippo-YAP in podocyte health and disease
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Jun 2025Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025ActinsAcuteAdhesion PlaquesAlbuminuriaArchitectureAutoregulationBiopsyCa2+-Activated K+ ChannelsCalcium Ion SignalingCalcium SignalingCalcium-Activated K+ ChannelsCalcium-Activated Potassium ChannelCell Communication and SignalingCell DifferentiationCell Differentiation processCell SignalingCell-Matrix Adherens JunctionsCellular MatrixCellular MorphologyChIP assayComplexCytoplasmCytoskeletal SystemCytoskeletonDataDiseaseDisease ProgressionDisorderEngineering / ArchitectureFSGSFocal AdhesionsFocal ContactsFocal and Segmental GlomerulosclerosisFocal segmental glomerular sclerosisGene ExpressionGenesGlomerular diseaseGoalsHealthHomeostasisHumanIn vivo analysisInjuryIntracellular Communication and SignalingK channelK elementKidneyKidney DiseasesKidney Urinary SystemKinasesKnowledgeLeftMediatingMedicinal ChemistryMiceMice MammalsModelingModern ManMolecularMurineMusNephropathyNuclearOntologyPathogenesisPathogenicityPathway interactionsPatientsPharmaceutic ChemistryPharmaceutical ChemistryPhosphorylationPhosphotransferase GenePhosphotransferasesPhysiological HomeostasisPotassiumPotassium ChannelPotassium Ion ChannelsPredispositionProtein PhosphorylationPurine ReceptorsPurinergic ReceptorsPurinoceptorRNA SeqRNA sequencingRNAseqRegulationRenal DiseaseRenal Glomerular Diseases and SyndromesRenal glomerular diseaseRenal glomerular disease or syndromeRenal glomerular disorderRenal glomerular syndromeRepressionResearchRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSusceptibilityTestingTransphosphorylasesVisceral Epithelial CellWorkbiological signal transductioncell morphologycellular differentiationchromatin immunoprecipitationclinical developmentclinical relevanceclinically relevantdisease modeldisorder modelefficacy testingglomerular filtrationglomerular visceral epithelial cellin vivoin vivo Modelin vivo evaluationin vivo testinginhibitorinjuriesintracellular skeletonkidney disorderknock-downknockdownnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetpathwaypharmacologicpodocyteprotein expressionrational designrenalrenal disordersocial roletherapeutic agent developmenttherapeutic developmenttherapeutic targettranscriptome sequencingtranscriptomic sequencingtranscriptomics
Description preview
Project Summary
A limited understanding of clinically relevant signaling pathways has limited the development of therapeutic
agents for human glomerular disease. Our long-term goal is to identify novel therapeutic targets for the treatment
of glomerular disease by elucidating the details and functional significance of key signaling pathways that…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click