grant
Hijacking the neonatal Fc receptor: the novel biology of arterivirus entry, transmission, and persistence
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 3 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY202621+ years old7S Gamma GlobulinAcuteAcute DiseaseAdultAdult HumanAnatomic SitesAnatomic structuresAnatomyAnimalsArteriviridaeArterivirusArterivirus InfectionsBiologyBlind SpotsBody TissuesCRISPRCRISPR/Cas systemCell BodyCell Culture TechniquesCell LineCell Surface GlycoproteinsCell Surface ReceptorsCellLineCellsCells Placenta-TissueClustered Regularly Interspaced Short Palindromic RepeatsComplexCoronaviridaeCoronavirusDevelopmentDiseaseDisorderDistantDysfunctionFamilyFamily suidaeFarmFc ReceptorFcRnFcRn neonatal transfer proteinFetusFunctional disorderGlycoproteinsGoalsHost FactorHost Factor ProteinHumanIgGImageImmune systemImmunityImmunoglobulin GIndustryInfectionIntegration Host FactorsKO miceKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLaboratoriesLactate Dehydrogenase VirusLactate dehydrogenase-elevating virusLactic Dehydrogenase VirusLife CycleLife Cycle StagesLinkLong-term infectionMacrophageMammaliaMammalsMapsMediatingMembrane GlycoproteinsMiceMice MammalsModelingModern ManMolecularMurineMusMφNormal PlacentomaNull MouseOrthocoronavirinaeOrthologOrthologous GenePhasePhysiologicPhysiologicalPhysiopathologyPigsPlacentaPlacenta BiologyPlacenta Embryonic TissuePlacental BiologyPlacentomePneumoniaPopulationPositionPositioning AttributePredispositionPrimatesPrimates MammalsProcessPublic HealthRNA VirusesReceptor ProteinRecoveryReporterResearchResistanceRetinal blind spotRiley VirusRoleSiteStrains Cell LinesStructureSuidaeSurfaceSurface GlycoproteinsSusceptibilitySwineSyncytiotrophoblastSystemTimeTissuesTransmissionTropismVertical TransmissionViralViral Hemorrhagic FeversViral ReceptorViremiaVirionVirusVirus ParticleVirus ReceptorsVirus ReplicationWhole Organismacute disease/disorderacute disorderadulthoodantibody receptorcell culturecell culturescell immortalizationchronic infectioncorona viruscross-species spillovercross-species transmissioncultured cell linedevelopmentaleconomic impactenzyme elevating virus (LDH)fetalgenome scalegenome-widegenomewidehemorrhagic feverhost jumphost switchingimagingin uteroin vivoinsightinterspecies transmissionlactic dehydrogenase elevating viruslife coursemedical countermeasuremodel organismnano-luciferasenanoluciferaseneglectneonatal Fc receptornovelpathophysiologypermissivenesspersistent infectionporcinepregnantreceptorresistantreverse geneticssocial rolesuidtime usetransmission across speciestransmission between speciestransmission processtransmitted across speciestransmitted between speciestransmitted cross-speciesviraemiaviral multiplicationviral replicationviral sepsisvirus multiplicationvirusemia
Description preview
PROJECT SUMMARY/ABSTRACT
Understanding novel mechanisms by which animal viruses enter cells, evade immunity, and cause disease has
scientific and public health importance. Arteriviruses are an understudied family of RNA viruses (related to
coronaviruses) that infect a wide variety of mammals. The host and viral factors that determine arterivirus…
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