grant
High-throughput closed-loop direct aberration sensing and correction for multiphoton imaging in live animals
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 1 Mar 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20252-photon21+ years old3-D3-Dimensional3-photon microscopy3DAcuteAdultAdult HumanAnimalsAttenuatedBehaviorBiological FunctionBiological ProcessBiomedical ResearchBody TissuesBrachydanio rerioBrainBrain Nervous SystemCancer BiologyCell CommunicationCell Communication and SignalingCell InteractionCell LocomotionCell MigrationCell MovementCell SignalingCell-to-Cell InteractionCellular MigrationCellular MotilityComplexDanio rerioDendritic CellsDeteriorationElasticityEncephalonFluorescenceFoundationsGoalsHeatingIlluminationImageImaging DeviceImaging InstrumentImaging ToolImmune responseImmunologyInterference MicroscopyIntracellular Communication and SignalingLaser ElectromagneticLaser RadiationLasersLightLightingLymph Node Reticuloendothelial SystemLymph node properLymphatic nodesMeasurementMeasuresMethodsMiceMice MammalsMicrointerferometryMicroscopeMicroscopic InterferometryMicroscopyMurineMusMuscleMuscle TissueNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurosciencesNoiseOperative ProceduresOperative Surgical ProceduresOptical MethodsOrganismPenetrationPhasePhotobleachingPhotonsPhotoradiationPredispositionProceduresProcessResearchResearch SpecimenResectedResolutionScanningScientistSignal TransductionSignal Transduction SystemsSignalingSliceSourceSpecificitySpecimenSpeedSurgicalSurgical InterventionsSurgical ProcedureSusceptibilitySystemT-CellsT-LymphocyteTechniquesTechnologyThalamic structureThalamusTimeTissue SampleTissue imagingTissuesTubeVeiled CellsZebra DanioZebra FishZebrafishadaptive opticsadulthoodattenuateattenuatesbiological signal transductioncareercell imagingcell motilitycellular imagingconfocal imagingfluorophorehost responseimagingimmune system responseimmunoresponseimprovedin vivoliving systemlymph glandlymph nodeslymphnodesmulti-photonmulti-photon imagingmultiphoton excitation microscopymultiphoton imagingmultiphoton microscopymuscularnano meter scalenano meter sizednanometer scalenanometer sizednanoscaleneuronalnew technologynon-invasive systemnoninvasive systemnovelnovel technologiesphotomultiplierprogramsreconstructionresolutionssub micronsubmicronsurgerythalamicthree dimensionalthree photon microscopythymus derived lymphocytetissue phantomtooltwo-photon
Description preview
Project Summary
This project aims to deliver real-time aberration-corrected multiphoton imaging with improved signal-to-
noise-ratio (SNR) and spatial resolution for studying turbid deep-tissue (~2 mm) of living animals at the cellular
level. Multiphoton microscopy (MPM) has been a useful tool to study biological processes due to its high…
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