grant
High-resolution structural analysis of native amphotericin megasynthases
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026Acyl Carrier ProteinAmBAmBisomeAmphocilAmphotecAmphotercin BAmphotericinAmphotericin BAnabolismArchitectureBacteriaBiologic ModelsBiological ModelsCarrier ProteinsClinicalCollectionColorComplexCryo-electron MicroscopyCryoelectron MicroscopyDevelopmentElectron CryomicroscopyElementsEngineering / ArchitectureEnzyme GeneEnzymesEventFamily memberFungizoneGenesGoalsIndividualLaboratoriesMacromolecular StructureMechanicsMedicineMetabolic GlycosylationMetabolic PathwayMethodologyModel SystemModelingModificationMolecularMolecular StructureMolecular WeightMysteclin-FNatural ProductsNystatinNystexOrganismPKS enzymePathway interactionsPeptide DomainProtein DomainsProteinsProteomeReportingResolutionSiteStreptomycesStretchingStructureTRAP ComplexTRAP MediatorTRAP/Mediator ComplexTechniquesTechnologyTertiary Protein StructureTherapeuticThyroid Hormone Receptor-Associated Protein ComplexTransport Protein GeneTransport ProteinsTransporter ProteinType I Polyketide SynthaseVisualizationWorkbiosynthesiscrosslinkcryo-EMcryoEMcryogenic electron microscopydesigndesigningdevelopmentaldrug discoveryglycosylationhigh definitionhigh-resolutionliving systemmanufacturemechanicmechanicalmycostatinnaturally occurring productnew drug treatmentsnew drugsnew pharmacological therapeuticnew technologynew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel technologiesnovel therapeuticsnovel therapyoxidationparticlepathwaypolyketide synthasepolyketidesprogramsprotein crosslinkprotein protein interactionreconstructionresolutionsstructural biologytherapeutic agent developmenttherapeutic developmenttooltool development
Description preview
Project Summary. Polyketide natural products have provided critical therapeutics, and they will remain an
important component of new drug discovery and manufacturing. This program aims to develop new technologies
to enable the high resolution cryo-EM structural elucidation of Type I polyketide synthases (PKSs) isolated
directly from natural…
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