grant
High resolution profiling and computational modeling of influenza virus-immune dynamics during natural infection
Organization UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGNLocation CHAMPAIGN, UNITED STATESPosted 1 Feb 2025Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY2025AddressAnimal ModelAnimal Models and Related StudiesAntibodiesAntigensB cell repertoireBloodBlood Reticuloendothelial SystemCOVID crisisCOVID epidemicCOVID pandemicCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 yearsCessation of lifeClinical ResearchClinical StudyCohort StudiesComplexComputer ModelsComputerized ModelsConcurrent StudiesDataData SetDeathDevelopmentDimensionsEvaluationEvolutionFrequenciesFundingFutureHost FactorHost Factor ProteinHumanIllinoisImmuneImmune memoryImmune responseImmunesImmunityImmunochemical ImmunologicImmunologicImmunologic MemoryImmunologic ModelImmunologicalImmunological MemoryImmunological ModelsImmunologicallyImmunologicsIndividualInfectionInfluenza BInfluenza B VirusInfluenza VaccinesInfluenza VirusInfluenza Viruses Type BIntegration Host FactorsKnowledgeMath ModelsMemoryModelingModern ManNIAIDNational Institute of Allergy and Infectious DiseaseOrthomyxoviruses Type BOutcomeParticipantPerformancePersonsPopulationProbabilistic ModelsProbability ModelsProcessProtocolProtocols documentationPublic HealthResolutionRiskSARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 pandemicSARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSamplingSevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicShapesStatistical ModelsTestingTransmissionUniversitiesVaccinationVaccinesViralViral DiseasesViral SheddingVirusVirus DiseasesVirus Sheddinganamnestic reactionanti-fluanti-influenzaantiflucohortcomputational modelingcomputational modelscomputer based modelscomputer based predictioncomputerized modelingcoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19 global pandemiccoronavirus disease-19 pandemicdesigndesigningdevelopmentalflu infectionflu vaccineflu virus infectionflu virus pandemicflu virus vaccinehigh dimensionalityhost responseimmune system responseimmunogenimmunological statusimmunoresponseinfected with fluinfected with flu virusinfected with influenzainfected with influenza virusinfection riskinfluenza infectioninfluenza virus infectioninfluenza virus pandemicinfluenza virus vaccineinfluenzavirusinsightlongitudinal data setlongitudinal datasetmachine statistical learningmathematic modelmathematical modelmathematical modelingmodel of animalmultidisciplinarynext generationnovelpan influenza vaccinepan influenza viral vaccinepan influenza virus vaccinepandemic flupandemic influenzapandemic strain of influenzapredictive modelingresolutionsresponsescreening programseasonal fluseasonal influenzasecondary immune responsesevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsingle cell analysisstatistical and machine learningstatistical linear mixed modelsstatistical linear modelsstatisticstransmission processuniversal flu vaccineuniversal influenza vaccineuniversal influenza virus vaccineuniversal vaccine against fluuniversal vaccine against influenzavaccine against fluvaccine against influenzavaccine candidateviral infectionviral transmissionvirus infectionvirus transmissionvirus-induced disease
Description preview
Abstract
Seasonal influenza viruses (IVs) cause hundreds of thousands of deaths every year, despite widespread pre-
exposure and vaccination. To design more effective vaccines against both seasonal and pandemic IVs, there is
an urgent need to better understand how the complex interplay between viral and immune dynamics in humans
influence…
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