grant
Hexokinase 1 mitochondrial binding and its role in cardiac endothelial cell function and the development of HFpEF
Organization UNIVERSITY OF ARIZONALocation TUCSON, UNITED STATESPosted 15 Jul 2025Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AgeBindingBlood VesselsCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCardiacCas nuclease technologyCell FunctionCell NucleusCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessChIP SequencingChIP-seqChIPseqClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyD-GlucoseDefectDevelopmentDextroseDiastolic heart failureDifferential Gene ExpressionDiseaseDislocationsDisorderDysfunctionEndothelial CellsEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquilibriumExonsFunctional disorderGenesGlucoseHF with preserved ejection fractionHFpEFHeartHexokinase DHexosaminesHistonesHydrophobicityImmunofluorescenceImmunofluorescence ImmunologicIsoformsKnowledgeMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasurementMediatingMetabolic GlycosylationMethodsMiceMice MammalsMitochondriaMolecularMolecular InteractionMurineMusN-terminalNH2-terminalNuclearNuclear ProteinsNucleusO-GlcNAc Transferase geneO-GlcNAc transferaseO-GlcNAcaseOuter Mitochondrial MembranePathogenesisPathway interactionsPhosphorylationPhysiopathologyPlayProtein GlycosylationProtein InhibitionProtein IsoformsProtein PhosphorylationProteinsRNA SeqRNA sequencingRNAseqRoleSamplingShort interfering RNASmall Interfering RNASubcellular ProcessTestingTissue-Specific Differential Gene ExpressionTissue-Specific Gene Expressionagesangiogenesisbalancebalance functioncardiac functionchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingclinical relevanceclinical significanceclinically relevantclinically significantdensitydevelopmentalendothelial dysfunctionepigeneticallyfunction of the heartglycosylationheart failure with preserved ejection fractionheart failure with preserved systolic functionheart functionhexokinasehexokinase IVimprovedin vivoinhibit proteininhibit proteinsinhibitormetabolism measurementmetabolomicsmetabonomicsmitochondrialmouse modelmurine modelnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoverexpressoverexpressionpathophysiologypathwaypeptide O-GlcNAc-beta-N-acetylglucosaminidasepeptide O-linked N-acetylglucosamine-beta-N-acetylglucosaminidasepreserved ejection fraction heart failureprotein inhibitionssiRNAsocial roletranscriptome sequencingtranscriptomic sequencingvascular
Description preview
Heart failure (HF) with preserved ejection fraction (HFpEF) is a prevalent disorder; however, our treatment
options are limited. Studies show that endothelial cell (EC) dysfunction precedes the development of HFpEF and
is a key player in the pathogenesis of this disorder. Hexokinases (HK) catalyze glucose phosphorylation, and
one HK isoform (HK1)…
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