grant
Hematopoietic Regulation via GATA Switches
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 1 Feb 2006Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY2025AML - Acute Myeloid LeukemiaAML/MDSAcute Myeloblastic LeukemiaAcute Myelocytic LeukemiaAcute Myelogenous LeukemiaAllelesAllelomorphsAssayAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBenignBioassayBiologicalBiological AssayBlood CellsBlood DiseasesBlood Precursor CellBlood monocyteBone MarrowBone Marrow Reticuloendothelial SystemCell BodyCell Communication and SignalingCell SignalingCellsChromatinChromatin Remodeling ComplexChromatin Remodeling FactorChronic Granulocytic LeukemiaChronic Myelocytic LeukemiaChronic Myelogenous LeukemiaChronic Myeloid LeukemiaClinicalClinical geneticsCodeCoding SystemConsultDNA BindingDNA Binding InteractionDNA boundDNA mutationDefectDevelopmentDysfunctionDysmyelopoietic SyndromesERYF1Emberger syndromeEndowmentEnhancersEnsureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessErythropoiesisFetal LiverFingersFoundationsFunctional disorderGATA Binding Protein 1GATA-1GATA1GATA1 geneGATA1 proteinGATA1 transcription factorGATA2 deficiencyGATA2 haploinsufficiencyGF-1 proteinGene variantGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGeneticGenetic ChangeGenetic DiversityGenetic ScreeningGenetic VariationGenetic defectGenetic mutationGenomeGenotypeGerm LinesGerm-Line MutationGranulopoiesisHematologic Body SystemHematologic DiseasesHematologic Organ SystemHematological DiseaseHematological DisorderHematopoiesisHematopoieticHematopoietic Body SystemHematopoietic Cellular Control MechanismsHematopoietic Progenitor CellsHematopoietic SystemHematopoietic stem cellsHereditary MutationHeterozygoteHumanHuman ActivitiesHuman GeneticsImmuneImmunesImmunodeficiency DisorderImmunodeficiency SyndromeImmunologic Deficiency SyndromesImmunological Deficiency SyndromesImpairmentInternationalIntracellular Communication and SignalingLifeLiver Stem CellMarrow monocyteMediatingMedical GeneticsMedical centerMiceMice MammalsModelingModern ManMolecularMonoMACMurineMusMutationMyelodysplastic DiseaseMyelodysplastic SyndromesMyeloid DiseaseMyeloid MalignancyMyeloid NeoplasmMyeloid TumorMyeloproliferative DisordersMyeloproliferative TumorsMyeloproliferative diseaseNF-E1 erythroid-specific transcription factorNFE1 proteinNucleotidesOutcomePathogenesisPathogenicityPathologicPatientsPeripheral Blood CellPhenotypePhysiciansPhysiologicPhysiologicalPhysiopathologyPolyvinyl AlcoholPreventative strategyPrevention strategyPreventive strategyProcessProgenitor CellsProteomeRefractory Anemia with an Excess of BlastsRefractory anaemia with excess blastsRegimenRegulationReportingResearchSignal TransductionSignal Transduction SystemsSignalingSiteSmoldering LeukemiaSomatic MutationSyndromeSystemTestingTherapeuticTranscription Factor GATA1Transcription Factor Proto-OncogeneTranscription factor genesVariantVariationWorkacute granulocytic leukemiaacute granulocytic leukemia cellacute myeloblastic leukemia cellacute myelocytic leukemia cellacute myelogenous leukemia cellacute myeloid leukemiaacute myeloid leukemia cellacute myeloid leukemia/myelodysplastic syndromeacute nonlymphocytic leukemia cellallelic variantbiologicbiological signal transductionblood cell formationblood cell progenitorblood disorderblood progenitorblood stem cellblood-forming stem cellchromatin modifierclinical centerclinical practiceconsultsdevelopmentaldiagnostic approachdiagnostic strategydisease causing variantdisease-causing alleledisease-causing mutationdrivingepigenetic gene silencingepigenetic silencingepigeneticallyerythroid developmentextracellularforginggain of functiongenetic variantgenome mutationgenomic variantgerm-line defectgermline variantglobal gene expressionglobal transcription profileglobin transcription factor 1hematopoietic progenitorhematopoietic stem progenitor cellhemopoietichemopoietic progenitorhemopoietic stem cellhepatic progenitorhepatic stem cellheterozygosityhomopolymer Ethenolhypoimmunityimmune deficiencyimmune deficiency disorderimmunodeficiencyin vivoinnovateinnovationinnovativeliver progenitormonocytemouse modelmultiomicsmultiple omicsmurine modelmutantmyelodysplasiamyeloproliferative neoplasmnovelnuclear factor-erythroid 1panomicspathogenic allelepathogenic variantpathophysiologyprogenitorprogenitor cell expansionprogenitor cell fateprogenitor cell functionprogenitor cell modelprogenitor expansionprogenitor fateprogenitor functionprogenitor modelprogramsresponsesomatic variantstem and progenitor cell expansionstem and progenitor cell fatestem and progenitor cell functionstem and progenitor cell modelstem and progenitor functionstem cell based modelstem cell derived modelstem cell expansionstem cell fatestem cell functionstem cell modelstem cellstranscription factortranscription factor NFE-1transcriptometransplant therapytransplant treatmenttransplantation therapytransplantation treatment
Description preview
ABSTRACT
Our program to forge principles for how GATA factors act through chromatin to control development,
function and dysfunction of the hematopoietic system discovered conserved Gata2 enhancers (+9.5 and -77)
that ensure normal hematopoiesis. There were no reports of enhancers essential for stem cell generation or
progenitor fate decisions,…
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