grant
Hearing regeneration in zebrafish
Organization NATIONAL HUMAN GENOME RESEARCH INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY202521+ years oldAblationAdultAdult HumanAffectBasal Transcription FactorBasal transcription factor genesBinding SitesBrachydanio rerioCell BodyCell IsolationCell SegregationCell SeparationCell Separation TechnologyCellsChemical ExposureChemicalsCombining SiteCommunitiesCorti CellDNA mutationDanio rerioDataDefectDevelopmentEmbryoEmbryologyEmbryonicEnhancersFertilizationFishesGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomicsGoalsHair CellsHearingHumanInbreedingInternal EarLabyrinthMammaliaMammalsMapsMeasurableMeasuresModelingModern ManMolecularMorphologyMutateMutationNatural regenerationNatureNeural ReceptorsNeuroreceptorsOrganParentsPhenotypePhysiologyProcessRNA ExpressionReactive SiteReceptor ProteinRecoveryRegenerationRegenerative responseResearchSensory ReceptorsSiblingsStartle ReactionSystemTestingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransgenic ModelTransgenic OrganismsVisualZebra DanioZebra FishZebrafishadulthoodcell agecell sortingcellular agedevelopmentalear developmentear hair cellexperimentexperimental researchexperimental studyexperimentsfertilizationsgene regulatory networkgenome mutationgood hearinghair cell regenerationhealthy hearingin vivoinner earinterestlateral linemodel organismmutantnormal hearingoffspringparentprogenitor cell nicheprogenitor nichereceptorregenerateregeneration responsescATAC sequencingscATAC-seqscreeningscreeningssingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell sequencing assay for transposase accessible chromatinsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqstartle responsestem and progenitor cell nichestem cell nichetranscription factortransgenictransgenic trait
Description preview
The Developmental Genomics Section has been using a combination of zebrafish genetics and molecular embryology to study ear development and hearing regeneration.
We have initiated research on hair cell regeneration in adult zebrafish. Using a transgenic ablation system, we cause measurable hearing damage. We then measured the transcriptional and…
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