grant

Harnessing protein clustering to understand, identify, and manipulate cellular systems

Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Aug 2020Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025Animal BehaviorAvidityBindingBiologicalBiological MarkersBiotechBiotechnologyCancersCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessComplementComplement ProteinsDevelopmentDiseaseDisorderDrugsEngineeringFoundationsImmune systemKineticsLightMalignant CellMalignant NeoplasmsMalignant TumorMammalian CellMedicationMethodsMolecularMolecular InteractionNerve DegenerationNeuron DegenerationPathologicPathologyPharmaceutical PreparationsPhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellPlayProcessPropertyProtein EngineeringProteinsReaction TimeResponse RTResponse TimeRoleSubcellular ProcessSystemTechnologyTimeViral DiseasesVirus DiseasesVisual ReceptorWorkbio-markersbiologicbiologic markerbiological systemsbiomarkercancer cellcomplementationcostcytokinedetection platformdetection systemdevelopmentaldrug/agentflexibilityflexiblegenetic protein engineeringinsoluble aggregatemalignancyneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoptogeneticsprotein aggregateprotein aggregationprotein designpsychomotor reaction timerecruitresponsesocial rolesynthetic proteintherapeutic targettoolviral infectionvirus infectionvirus-induced disease
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Summary/Abstract
The Bugaj Lab develops precision-controlled molecular tools to better understand and control biological

systems. This proposal will develop technologies that harness protein clustering for new, enabling methods to

study, manipulate, and treat cells. Protein clustering plays important roles throughout cell physiology and

disease,…

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Harnessing protein clustering to understand, identify, and manipulate cellular systems — UNIVERSITY OF PENNSYLVANIA | UN | Dev Procure