grant
Harnessing Diverse Bioinformatic Approaches To Repurpose Drugs For Alzheimers Disease And Related Dementias
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 30 Sept 2018Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AD dementiaAD related dementiaADRDAccelerated PhaseAccelerationAffinityAllelism TestAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's Disease PathwayAlzheimer's and related dementiasAlzheimer's brainAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease brainAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease patientAlzheimer's disease related dementiaAlzheimer's patientAlzheimers DementiaAmentiaAwardAwarenessBig DataBigDataBioinformaticsBiological MarkersBiologyBrainBrain Nervous SystemBrain regionCell BodyCell Communication and SignalingCell SignalingCellsChemicalsClinicalClinical InvestigatorClinical ResearchClinical StudyClinical TrialsClinical Trials DesignCollaborationsCommunitiesCompensationComplementation TestComputational toolkitComputer SystemsComputer softwareDataData BasesData SetDatabasesDementiaDiagnosisDiseaseDisease ProgressionDisorderDrug PrescribingDrug PrescriptionsDrug TargetingDrug usageDrugsEconomicsElectronic Health RecordEncephalonEvaluationEventExonsExpression SignatureFDA approvedGene ExpressionGene Expression ProfileGenetic Complementation TestGenomeGliaGlial CellsHumanIndividualIndustryInflammatoryInformaticsInfrastructureIntracellular Communication and SignalingIsraelKidney FailureKidney InsufficiencyKnowledgeKolliker's reticulumLaboratoriesLeadLiteratureMachine LearningMedicationMedicineMendelian randomizationMethodologyMethodsModelingModern ManNational Health ServicesNerve CellsNerve UnitNetwork AnalysisNeural CellNeurocyteNeurofibrillary TanglesNeurogliaNeuroglial CellsNeuronsNew AgentsNon-neuronal cellNonneuronal cellOnset of illnessOutcomePathologicPathologyPathway AnalysisPathway interactionsPatientsPatternPb elementPeripheralPharmaceutical PreparationsPharmacologyPhase 2 Clinical TrialsPhase II Clinical TrialsPhenotypePlacebo ControlPreventionPrimary Senile Degenerative DementiaProductionProteomeProteomicsProxyPublic DomainsRNA SeqRNA sequencingRNAseqRandomizedRecordsRenal FailureRenal InsufficiencyReproducibilityRiskRunningSignal TransductionSignal Transduction SystemsSignalingSingle Base PolymorphismSingle Nucleotide PolymorphismSiteSoftwareStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationSymptomsSynapsesSynapticSystemTAR DNA binding protein 43 kDa pathologyTAR DNA binding protein 43 pathologyTAR DNA binding protein of 43 proteinopathyTDP43 associated neurodegenerationTDP43 associated neurodegenerative diseaseTDP43 associated pathologiesTDP43 induced neurodegenerationTDP43 neurodegenerationTDP43 neurodegenerative diseaseTDP43 neuropathologyTDP43 pathogenesisTDP43 pathologyTDP43 proteinopathyTDP43 related neurodegenerationTDP43 related pathologyTarget PopulationsTestingTherapeuticTherapeutic Clinical TrialTrans TestTrans active response DNA binding protein 43 pathologyTrans active response DNA binding protein of 43 kDa proteinopathyUpdateWorkbio-markersbiobankbiologic markerbiological signal transductionbiomarkerbiorepositorycandidate identificationcell typechemical informaticscheminformaticsclinical careclinical relevanceclinically relevantcomplementation analysiscomplementation approachcomputational toolboxcomputational toolscomputational toolsetcomputer sciencecomputerized toolscomputing systemcostdata basedementia carediscover genesdisease onsetdisorder onsetdrug actiondrug candidatedrug repositioningdrug repurposingdrug usedrug/agenteconomicelectronic health care recordelectronic health medical recordelectronic health plan recordelectronic health registryelectronic medical health recordfederated learninggene discoverygene expression patterngene expression signatureglobal gene expressionglobal transcription profileheavy metal Pbheavy metal leadimaging studyimprovedinhibitorinteroperabilitykinase inhibitorlarge data setslarge datasetsmachine based learningmedication prescriptionmeetingmeetingsmembermultidisciplinarynerve cementneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneuronalnovelopen dataopen scienceopen sourceopen-source datapathwaypatient living with Alzheimer's diseasepatient populationpatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasephase 3 trialphase II protocolphase III trialplacebo controlledpredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerpreferenceprescribed medicationpreventpreventingprimary degenerative dementiaprogramsprospectiveprotein expressionrandomisationrandomizationrandomly assignedreal world evidencerepurposing agentrepurposing medicationresponsesenile dementia of the Alzheimer typesingle nucleotide variantstatistical analysissynapsetangletooltrans active response DNA binding protein 43 kDa pathologytrans active response DNA binding protein 43 proteinopathytranscriptional profiletranscriptional signaturetranscriptometranscriptome sequencingtranscriptomic sequencingtranslational study
Description preview
Abstract
The exploration of genomes, transcriptomes, and proteomes derived from brains with Alzheimer's disease
(AD) by powerful computational tools has developed new knowledge, including the identification of pathways
and targets that may be involved in the initiation and/or progression of the disease. The challenge is to find
drugs that impact…
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