grant
Harnessing commensal redox metabolism in infection prevention
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 24 Nov 2023Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY2026AblationAcuteAffectAlditolsAmino AcidsAminoacetic AcidAnaerobic BacteriaAntibiotic AgentsAntibiotic DrugsAntibioticsAutomobile DrivingBiomassBody TissuesC diffC difficileC. diffC. difficileCarbohydratesCarbonChlolincocinChlorlincocinChronicClindamycinClostridioides difficileClostridiumClostridium difficileComplexConsumptionD-GlucoseD-MannitolDextroseDietDiseaseDisorderEnvironmentEquilibriumEventExposure toFermentationGI colonizationGene ExpressionGeneralized GrowthGenerationsGenomeGerm-FreeGlucoseGlycineGnotobioticGnotobioticsGrowthIn VitroInfectionInfection preventionIntermediary MetabolismInterventionIntestinalIntestinesL-ProlineLabelLeucineMagicMannitolMetabolicMetabolic ProcessesMetabolismMiceMice MammalsMicronutrientsMiscellaneous AntibioticMolecularMurineMusNutrientNutrient DepletionNutrient availabilityOralOral AdministrationOral Drug AdministrationOsmitrolOutcomeOxidation-ReductionPathogenesisPathway interactionsPhenotypePrevent infectionProcessProductionProlineRedoxResectisolResolutionRoleSourceSubstrate InteractionSugar AlcoholsSweetenersSweetening AgentsSystemTissue GrowthTissuesToxinVirulenceWorkXylitolabsorptionamino acid metabolismaminoacidanaerobebacteria metabolismbacteria pathogenbacterial metabolismbacterial pathogenbalancebalance functionboweldietarydietsdisease preventiondisorder preventiondrivinggastrointestinal tract colonizationgut colonizationhigh definitionhigh-resolutionin vivoinfection riskinnovateinnovationinnovativeintestinal colonizationintraoral drug deliverymicrobial consortiamicrobial floramicrobiotamicrofloramouse modelmultispecies consortiamurine modelontogenyoxidation reduction reactionpathogenpathogenic bacteriapathwayprogramsrecruitresolutionsrisk mitigationsmall moleculesocial roletoxin metabolism
Description preview
Abstract: Many gut-infecting bacterial pathogens undergo growth expansion in the gut lumen as
part of the virulence, and as supported by their underlying metabolism. Commensal metabolism
in the gut provides an opportunity to impede these processes by depriving pathogens of growth-
promoting nutrients. Using the amino acid and…
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