grant
Harnessing activated CD4 T cells to define new mechanisms of protection in tuberculosis
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AddressAdoptive TransferAgonistAntibiotic TherapyAntibiotic TreatmentAntibodiesAntigensBlood VesselsBody TissuesCD134CD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCITE sequencingCITE-seqCITEseqCause of DeathCell BodyCell CommunicationCell Communication and SignalingCell CountCell FunctionCell InteractionCell IsolationCell NumberCell PhysiologyCell ProcessCell SegregationCell SeparationCell Separation TechnologyCell SignalingCell SurvivalCell ViabilityCell-to-Cell InteractionCellsCellular FunctionCellular Indexing of Transcriptomes and Epitopes by SequencingCellular PhysiologyCellular ProcessCharacteristicsChronicClinical Treatment MoabClonal ExpansionDataDevelopmentDifferentation MarkersDifferentiation AntigensDifferentiation MarkersDiseaseDisorderFailureFluorescenceGene TranscriptionGenetic TranscriptionImmune mediated therapyImmunityImmunodominant Antigenic DeterminantsImmunodominant DeterminantsImmunodominant DomainsImmunodominant EpitopesImmunodominant RegionsImmunodominant SitesImmunologic ReceptorsImmunological ReceptorsImmunologically Directed TherapyImmunotherapeutic agentImmunotherapyInfectionIntracellular Communication and SignalingKnowledgeLong-term infectionLungLung ParenchymaLung Respiratory SystemLung TissueM tbM tuberculosisM tuberculosis antigenM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis antigenM. tuberculosis infectionM.tb antigenM.tb infectionM.tuberculosis infectionMHC ReceptorMTB infectionMTB vaccineMajor Histocompatibility Complex ReceptorMarker AntigensMediatingMediatorMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMiceMice MammalsMonoclonal AntibodiesMtb antigenMurineMusMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis antigensMycobacterium tuberculosis infectionOX40PersonsPhenotypePopulationPositionPositioning AttributeRNA ExpressionReceptor ProteinRegulatory T-LymphocyteReporterResolutionShapesSignal TransductionSignal Transduction SystemsSignalingSiteSpecificityStructure of parenchyma of lungSubcellular ProcessSurface ProteinsT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell receptor repertoire sequencingT cell receptor sequencingT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-Cell ActivationT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteT-cell therapeuticsT-cell transfer therapyT4 CellsT4 LymphocytesTB immunityTB infectionTB therapyTB treatmentTB vaccineTCR repertoire sequencingTCR sequencingTCR-seqTCRseqTeff cellTestingTherapeuticTimeTissuesToxic effectToxicitiesTranscriptionTregTuberculosisTuberculosis VaccinesVaccine for TBVaccine for TuberculosisVaccinesWorkactivate T cellsadaptive immunityadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyanti-TB vaccinebacterial disease treatmentbacterial infectious disease treatmentbiological signal transductioncell sortingcellular indexing of transcriptomes and epitopes by single cell sequencingchronic infectiondevelopmentaldisseminated TBdisseminated tuberculosiseffector T cellfightingimmune drugsimmune receptorimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmunity against M. tuberculosisimmunity against Mtbimmunity against Mycobacterium tuberculosisimmunity against TBimmunity against tuberculosisimmunity in tuberculosisimmunity to TBimmunity to tuberculosisimmuno therapyimmunogenimmunologic therapeuticsimmunotherapeuticsimmunotherapy agentimprovedin vivoinfection due to Mycobacterium tuberculosisinnovateinnovationinnovativelung functionmAbsmonoclonal Absmortalitymouse modelmtbmurine modelnew approachesnew markernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel approachesnovel biomarkernovel markernovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpersistent infectionpreventpreventingprogramsprotein expressionpulmonary functionreceptorregulatory T-cellsresolutionsscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingtherapeutic T-cell platformtherapeutic targetthymus derived lymphocytetraffickingtreat M. tuberculosistreat Mtbtreat Mycobacterium tuberculosistreat tbtreat tuberculosistuberculosis immunitytuberculosis infectiontuberculosis therapytuberculosis treatmenttuberculous spondyloarthropathyvaccine against M. tuberculosisvaccine against Mtbvaccine against Mycobacterium tuberculosisvaccine against TBvaccine against tuberculosisvaccine candidates against tuberculosisvascular
Description preview
CD4 T cells are essential for protection against tuberculosis (TB). But current approaches to TB therapy have
not harnessed their potential benefit, and the mechanisms they use to control Mycobacterium tuberculosis (Mtb)
have not been completely defined. At the peak of adaptive immunity to TB, millions of Mtb-specific CD4 T cells
traffic to the…
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