grant
H3 histone oxidation is a new posttranslational modification linking heavy metal-induced metabolic changes and oncegenic epigenetic reprogramming
Organization H. LEE MOFFITT CANCER CTR & RES INSTLocation TAMPA, UNITED STATESPosted 23 Sept 2025Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY20262,4-DNP2,4-DinitrophenolAbscissionActive OxygenAffectAmino AcidsAntioxidantsArsenicBasal Transcription FactorBasal transcription factor genesBiochemicalBone-Derived Transforming Growth FactorBreast CancerBreast Cancer CellBreast Cancer PatientBreast MetastasisBreast Tumor PatientCadmiumCancer PatientCancer PrognosisCancersCd elementCell BodyCell NucleusCell ReprogrammingCellsChromatinCommunicationCysteineDNPDataDevelopmentDinitrophenolsDiseaseDisease ProgressionDisease remissionDisorderDoseER PositiveER+EpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEstrogen receptor positiveExcisionExtirpationFDA approvedGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGenetic TranscriptionGenomicsH2O2Half-CystineHeavy MetalsHeterochromatinHistone H3HistonesHydrogen PeroxideHydroperoxideIntermediary MetabolismInterruptionInterventionL-CysteineL-SerineLab FindingsLaboratory FindingLeadLicensingLinkLiquid substanceMalignant Breast NeoplasmMalignant CellMalignant NeoplasmsMalignant TumorMetabolicMetabolic ProcessesMetabolismMetal exposureMetalsMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsMilk Growth FactorMitochondriaMulti-Drug ResistanceMultidrug ResistanceMultiple Drug ResistanceMultiple Drug ResistantMurineMusNeoplasm MetastasisNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersNuclearNucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesNucleosomesNucleusOxidation-ReductionOxidative StressOxygen RadicalsPathway interactionsPb elementPhase 2 Clinical TrialsPhase II Clinical TrialsPhenotypePlatelet Transforming Growth FactorPlayPoisonPoisoningPollutionPositionPositioning AttributePost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPrimary NeoplasmPrimary TumorPro-OxidantsProcessProductionProtective AgentsProtective DrugsProtein ModificationRNA ExpressionReactive Oxygen SpeciesRedoxRegulationRegulatory RegionsRemissionRemovalResearchResistanceResistance to Multi-drugResistance to MultidrugResistance to Multiple DrugResistant to Multiple DrugResistant to multi-drugResistant to multidrugRoleSecondary NeoplasmSecondary TumorSerineStem Cell likeSurgical RemovalTGF BTGF-betaTGF-βTGFbetaTGFβTestingTherapeuticTherapeutic InterventionTimeToxic ChemicalToxic SubstanceTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTreatment EfficacyTumor CellUncoupling AgentsVariantVariationacquired drug resistanceaminoacidarsenicsbreast cancer metastasisbreast cancer progressionbreast tumor cellcancer cellcancer cell metabolismcancer drug resistancecancer metabolismcancer metastasiscancer progenitorcancer progenitor cellscancer progressioncancer stem cellcancer stem like cellcatalasecellular reprogrammingchemotherapychromatin remodelingdevelopmentalepigenetic memoryepigeneticallyepithelial to mesenchymal transitionexposure to metalfluidgenetic regulatory elementheavy metal Pbheavy metal leadimprovedindividuals with breast cancerintervention efficacyintervention therapyliquidmalignancymalignant breast tumormalignant progenitormalignant stem cellmetal poisoningmetal toxicitymimeticsmitochondrialmitochondrial dysfunctionmortalitymulti-drug resistantmultidrug resistantmutantneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionneurological diseasenoveloncogenic progenitoroncogenic stem cellsoxidationoxidation reduction reactionpathwaypatients with breast cancerperson with breast cancerpharmacologicphase II protocolpoisonedpostmitoticpreservationpreventpreventingprogenitor capacityprogenitor cell likeprogenitor like cancer cellprogenitor-likeprogramsresectionresistance to cancer drugsresistance to therapyresistantresistant to cancer drugsresistant to therapysocial rolestem cell characteristicsstem like cancer cellstem-likestemnesstherapeutic efficacytherapeutic outcometherapeutic resistancetherapy efficacytherapy outcometherapy resistanttoxic compoundtranscription factortreatment resistancetumortumor cell metabolismtumor cell metastasistumor metabolismtumor progressiontumor xenograft
Description preview
Transcription stability enforces cellular identity and is tightly controlled by restrictions imposed on both transcription factor function and target gene accessibility. Progression of cancer to metastasis and multi-drug resistance requires fluid transcriptional programs that can explore different genomic landscapes to enable clonal…
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