grant
Gut Treg cells at the microbiome interface
Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 18 Nov 2024Deadline 31 Oct 2029
NIHUS FederalResearch GrantFY202521+ years oldAblationAdultAdult ChildrenAdult DaughtersAdult HumanAdult OffspringAdult SonsAffectAlimentary CanalAllergic to foodAllergy to foodAntigen-Presenting CellsAntigensBackBasal Transcription FactorBasal transcription factor genesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCRISPRCRISPR/Cas systemCell BodyCellsChromatinClustered Regularly Interspaced Short Palindromic RepeatsColonComplexDataDependenceDigestive TractDorsumE coliE. coliEcologic SystemsEcological SystemsEcosystemEngineeringEnhancer-Binding Protein GATA3EpitheliumEquilibriumEragrostisEscherichia coliExplosionFOXP3FOXP3 geneFilamentous FungiFoodFood AllergyFood HypersensitivityForkhead Box P3FrequenciesGATA-3 factorsGATA-3 proteinGATA-Binding Protein 3GATA3GATA3 geneGATA3 proteinGATA3 transcription factorGI TractGI colonizationGI microbiotaGastrointestinal TractGastrointestinal microbiotaGastrointestinal tract structureGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenerationsGeneticGenetic TranscriptionGoalsGrowthH hepaticusH. hepaticusHelicobacter hepaticusIgAImmune ToleranceImmunoglobulin AImmunologic ToleranceInfantInflammationInflammatoryIntestinalIntestinesInvadedJM2LabelLifeLineage TracingMaintenanceMeasuresMiceMice MammalsMicrobeMicrobial PhysiologyMilkMoldsMurineMusPeptide-MHCPeptide-Major Histocompatibility Protein ComplexPeptide/MHC ComplexPhasePhenotypePhysiologyPlayProductionRNA ExpressionRNA SeqRNA sequencingRNAseqRegulatory T-LymphocyteResearchRibosomal DNARoleSCURFINSEQ-ANSequence AnalysesSequence AnalysisShapesSpecificityT cell differentiationT-CellsT-LymphocyteT-cell receptor repertoireT4 CellsT4 LymphocytesTCR repertoireTeffTestingThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTimeTissue GrowthTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransgenic OrganismsTregVariantVariationWeaningaccessory celladulthoodalimentary tractanti-microbialantimicrobialbalancebalance functionbowelbowel inflammationcell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell typecellular lineage mappingcellular lineage trackingcommensal floracommensal microbescommensal microbiotacommensal microfloradigestive canalenteric microbial communityenteric microbiotafascinatefitnessfood antigengastrointestinal microbial floragastrointestinal tract colonizationgut colonizationgut communitygut floragut homeostasisgut inflammationgut microbe communitygut microbesgut microbial communitygut microbial compositiongut microbial consortiagut microbial speciesgut microbiotagut microbioticgut microfloraimmune system toleranceimmune unresponsivenessimmunogenimmunological paralysisimprintinflamed bowelinflamed gutinflamed intestineintestinal colonizationintestinal floraintestinal inflammationintestinal microbesintestinal microbiotaintestinal microfloraintestinal tract microfloramaternal imprintmicrobialmicrobial antigenmicrobial colonizationmicrobial consortiamicrobial floramicrobiomemicrobiotamicrofloramicroorganism antigenmultispecies consortianew approachesnovel approachesnovel strategiesnovel strategyontogenypMHCperinatal periodperinatal phasepost-natal periodpostnatalpostnatal periodpreventpreventingprogramsrDNAregulatory T-cellsresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesymbiontthymus derived lymphocytetissue repairtranscription factortranscriptome sequencingtranscriptomic sequencingtranscriptomicstransgenic
Description preview
Coexistence with the commensal microbes that populate the mammalian gastro-intestinal tract requires a
balance to prevent microbial invasion while tolerating symbionts and limiting inflammatory damage. FoxP3+ T
regulatory (Treg) cells play a central role in gut homeostasis. Conversely, the gut microbiota shapes local Treg
pools, in particular by…
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