grant
Gut Microbe-Derived Lipids Shape Chronic Inflammation in Cardiometabolic Disease
Organization CLEVELAND CLINIC LERNER COM-CWRULocation CLEVELAND, UNITED STATESPosted 1 May 2025Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY20262-amino-1,3-propanediolAPOEASCVDActive Follow-upAddressAdipose tissueAdult-Onset Diabetes MellitusAmidesAntiinflammatory EffectApo-EApoE proteinApolipoprotein EAssayAtherosclerosisAtherosclerotic Cardiovascular DiseaseBioassayBiological AssayBloodBlood Reticuloendothelial SystemBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemC57BL/6 MouseCardiac DiseasesCardiac DisordersCardiometabolic DiseaseCardiometabolic DisorderCell Communication and SignalingCell SignalingChronicChronotherapyCircadian DysregulationCirculationClinicalDevelopmentDiabetes MellitusDietDiseaseDisorderDoseDrug TargetingEndocrine Gland SecretionEndocrinologyEnvironmental FactorEnvironmental Risk FactorEnzyme GeneEnzymesFatsFatty TissueFatty acid glycerol estersFoam CellsG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGI microbiomeGPCRGPR119GPR119 receptorGenesGnotobioticGnotobioticsGoalsHeart DiseasesHeart failureHigh Fat DietHormonalHormonesHumanHumulin RInflammasomeInflammationInflammatoryInflammatory ResponseInnate Immune ResponseInsulinInsulin ResistanceIntermediary MetabolismIntestinalIntestinesIntracellular Communication and SignalingIsotopesJet LagJet Lag SyndromeJetlagJetlag SyndromeKO miceKetosis-Resistant Diabetes MellitusKnock-out MiceKnockout MiceL CellsLeptinLibrariesLightLinkLipidsMEFV gene productMacrophageMaturity-Onset Diabetes MellitusMeasuresMediatingMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMetabolism and EndocrinologyMethodsMiceMice MammalsMicrobeModelingModern ManMolecularMurineMusMφNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RNull MouseOb Gene ProductOb ProteinObese Gene ProductObese ProteinObesityPathway interactionsPatternPattern recognition receptorPeripheralPhasePhotoradiationPollutionProbioticsProductionProteinsReceptor Cross-TalkReceptor ProteinRegular InsulinSamplingShapesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusStable Diabetes MellitusSterolsSystemT2 DMT2DT2DMTestingTherapeuticTime Zone Change SyndromeTime Zone SyndromeTissuesTransplantationType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesactive followupadiposeadiposityadult onset diabetesanti-inflammatory effectatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebacteria in the gutbiological signal transductionbowelcardiac failurecircadian abnormalitycircadian clockcircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentcircadian pacemakercommensal bacteriacommensal bacterial speciescorpulencecytokineday shiftdevelopmentaldiabetesdiet-associated obesitydiet-induced obesitydiet-related obesitydietsdigestive tract microbiomedisease phenotypeenteric microbiomeenvironmental riskexperimentexperimental researchexperimental studyexperimentsfecal samplefollow upfollow-upfollowed upfollowupgain of functiongastrointestinal microbiomegut bacteriagut microbesgut microbial speciesgut microbiomegut-associated microbiomeheart disorderhost microbiotahost microflorahuman diseaseimprovedin vivoinnovateinnovationinnovativeinsulin resistantinsulin toleranceintestinal biomeintestinal microbesintestinal microbiomeketosis resistant diabeteslipokinesmarenostrinmaturity onset diabetesmicrobialmicrobiome communitymouse modelmurine modelnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnight shiftnight worknovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoverexpressoverexpressionpathwaypre-clinicalpreclinicalpreventpreventingprobiotic therapeuticprobiotic therapyprobiotic treatmentpublic health relevancepyrinreceptorresident microbesresident microfloraserinolshift workshiftworkstool samplestool specimentransplanttype 2 DMtype II DMtype two diabeteswhite adipose tissueyellow adipose tissue
Description preview
ABSTRACT
Recent evidence has emerged that microbes resident in the human intestine represent a key
transmissible environmental factor contributing to a number of human diseases including obesity,
diabetes, atherosclerotic cardiovascular disease. However, mechanisms by which gut microbial-
derived factors signal to the host to promote these common…
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