grant
Guide RNA Binding Complex
Organization BOSTON UNIVERSITY MEDICAL CAMPUSLocation BOSTON, UNITED STATESPosted 10 Jun 2012Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025ATP phosphohydrolaseATPaseAdenosine TriphosphataseAffinityAfrica South of the SaharaAntigen VariationAntigenic VariabilityAntigenic VariationAssayAutomobile DrivingBase PairingBindingBioassayBiochemicalBiochemistryBiogenesisBiologic ModelsBiologicalBiological AssayBiological ChemistryBiological ModelsBiologyClampingsClassificationClosure by LigationClosure by clampCodeCoding SystemComplexCoupledCryo-electron MicroscopyCryoelectron MicroscopyDNA HelicasesDNA Unwinding ProteinsDNA unwinding enzymeElectron CryomicroscopyEngineeringEnzyme GeneEnzymesEventFutureGeneticGenetics-MutagenesisGenomeGoalsGuide RNAHybridsIn VitroKnowledgeLigationLinkMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMechanicsMedicalMessenger RNAMitochondriaMitochondria RNAMitochondrial RNAModalityModel SystemModelingModificationMolecularMolecular InteractionMolecular MotorsMonitorMotorMutagenesisMutagenesis Molecular BiologyNon-Polyadenylated RNANucleotidesOrigin of LifeParasitesParasitic infectionParasitologyPathway interactionsPhosphatasesPhosphohydrolasesPhosphomonoesterasesPhosphoric Monoester HydrolasesPositionPositioning AttributePost-Transcriptional Gene SilencingPre-mRNAPrevalenceProcessProteinsProteomicsPseudogenesPublic HealthPutative RNA-Binding RegionRNARNA BindingRNA Binding DomainRNA EditingRNA Gene ProductsRNA HelicaseRNA InterferenceRNA Recognition MotifRNA SeqRNA SilencingRNA boundRNA sequencingRNA, Messenger, EditingRNA, Messenger, PrecursorsRNAiRNAseqRNP DomainRNP MotifRNP-1 SignatureRationalizationReactionRefractoryReportingResearchResolutionRibonucleic AcidRibonucleoproteinsRoleSequence-Specific Posttranscriptional Gene SilencingShapesSiteSpinal ColumnSpineStructural ModelsStructureSub-Saharan AfricaSubsaharan AfricaSystematicsT bruceiT. bruceiTailTechnologyTherapeuticTranscriptTranslatingTropical DiseaseTrypanosomaTrypanosoma bruceiTrypanosoma brucei bruceiTrypanosomeUrdUridineVertebral columnVisualizationWorkadenylatebackbonebasebasesbiologiccrosslinkcryo-EMcryoEMcryogenic electron microscopydrivingdrug repositioningdrug repurposingempowermentgRNAglobal gene expressionglobal transcription profilehelicasehuman pathogenin vivoindelinfected with parasitesinnovateinnovationinnovativeinsertion/deletioninsertion/deletion mutationmRNAmRNA Precursormechanicmechanicalmitochondrialmitochondrial mRNAmitochondrial messenger RNAmtRNAoverexpressoverexpressionparasite infectionparticlepathogenpathwayprotein complexprotein protein interactionreconstitutereconstitutionrepurposing agentrepurposing medicationresolutionsscaffoldscaffoldingself assemblysocial roletooltranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicstriphosphatetripolyphosphate
Description preview
SUMMARY
Parasitic infections caused by Trypanosoma brucei spp. have historically undermined public health and
economies in Sub-Saharan Africa, only partially curtailed by recently approved therapeutics. Although the long-
term impact of repurposed drugs remains unclear, sustained research has positioned T. brucei among the most
prolific…
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