grant
Growth suppressive and oncogenic transcriptional programs controlled by the androgen receptor in prostate cancer
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 1 Mar 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2025AR geneAndrogen ReceptorAndrogenic AgentsAndrogenic CompoundsAndrogensAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBiochemicalBiologic ModelsBiological ModelsBiologyCancer GenesCancer PatientCancer-Promoting GeneCancerousCancersCell BodyCell Communication and SignalingCell LineCell SignalingCellLineCellsDNA AlterationDNA MethylationDNA Sequence AlterationDNA mutationDNA-Binding ProteinsDataDihydrotestosterone ReceptorDisease ResistanceEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquilibriumExpression SignatureGEM modelGEMM modelGene ExpressionGene Expression ProfileGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGenetic AlterationGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenetically Engineered MouseGenomicsGrowthHumanIn VitroIntracellular Communication and SignalingMalignant NeoplasmsMalignant TumorMalignant neoplasm of prostateMalignant prostatic tumorMediatingMediatorModel SystemModelingModern ManMutationNR3C4Nucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesOncogenesOncogenesisOncogenicOrganoidsPatientsPhenotypePrognosisPrognostic MarkerProstateProstate CAProstate CA therapyProstate CancerProstate Cancer therapyProstate GlandProstate malignancyProstatic GlandProstatic ParenchymaProstatic TissuePublishingRNA ExpressionRNA SplicingReceptor SignalingRegulationRegulatory ElementRegulatory RegionsResponse ElementsRoleSMAX1SamplingSequence AlterationSignal TransductionSignal Transduction SystemsSignalingSplicingStrains Cell LinesSystemTestingTherapeutic AndrogenTissue GrowthTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTransforming GenesVariantVariationWorkadvanced prostate cancerandrogen receptor genebalancebalance functionbiological signal transductioncofactorcultured cell linedisease heterogeneitydrivingepigeneticallyepigenomicsfunctional genomicsgene expression patterngene expression signaturegenetic regulatory elementgenetically engineered mouse modelgenetically engineered murine modelgenome mutationgenomic alterationin vivoinnovateinnovationinnovativeinsightmalignancyneoplasm/cancernew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetontogenyoverexpressoverexpressionpatient populationpredict responsivenesspredicting responsepredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprognostic biomarkerprognostic indicatorprogramsprostate cancer cellprostate cancer modelprostate cancer treatmentprostate carcinogenesisprostate tumor cellprostate tumor modelprostate tumorigenesisreceptor expressionresistance to diseaseresistant diseaseresistant to diseaseresponseresponse to therapyresponse to treatmentsocial roletargeted agenttargeted cancer therapytherapeutic responsetherapeutic targettherapy responsetranscription factortranscriptional profiletranscriptional signaturetreatment responsetreatment responsivenesstreatment strategytumortumorigenesis
Description preview
PROJECT SUMMARY / ABSTRACT
The androgen receptor (AR) is the central determinant of prostate tissue identity and differentiation, controlling
normal, growth-suppressive gene expression associated with differentiation of prostate cells. It is also a key
driver of prostate tumorigenesis, becoming “hijacked” to drive oncogenic transcription. However,…
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