grant
Glycosylation in ocular surface health and disease
Organization TUFTS MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 1 Aug 2016Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AffectAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesBlindnessBrainBrain Nervous SystemCNS Nervous SystemCarbohydratesCell CoatCell Communication and SignalingCell SignalingCentral Nervous SystemClinicalCorneaCornea painCorneal DiseasesCorneal DisorderCorneal InjuryCorneal painCranial Nerve VDataDeoxygalactoseDevelopmentDiseaseDisorderDysfunctionEncephalonEnzyme GeneEnzymesEsthesiaEye painFeedbackFemaleFifth Cranial NerveFucoseFunctional disorderGasser's GanglionGasserian GanglionGliaGlial CellsGlycansGlycocalyxHealthImageImpairmentIn Situ HybridizationIndividualInfectionInflammatoryInjuryIntracellular Communication and SignalingIon ChannelIonic ChannelsKolliker's reticulumLabelLacrimal deficiencyLacrimal secretionLacrimationLectinMaintenanceMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMembrane ChannelsMetabolic GlycosylationMetabolic PathwayMiceMice MammalsMurineMusN-Acetylneuraminic AcidsNatural regenerationNerveNerve CellsNerve Impulse TransmissionNerve RegenerationNerve Tissue ProteinsNerve TransmissionNerve UnitNervous SystemNervus TrigeminusNeural CellNeuraxisNeuro-regenerationNeurocyteNeurogliaNeuroglial CellsNeurologic Body SystemNeurologic Organ SystemNeuronal TransmissionNeuronsNeuropathyNeuroregenerationNon-neuronal cellNonneuronal cellOcular desiccationPainPainfulPathogenesisPeripheral Nervous SystemPhysiopathologyPolysaccharidesProcessProteinsProteomicsRegenerationResearchScaffolding ProteinSemilunar GanglionSensationSensorySialic AcidsSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSingle-Nucleus SequencingStructureStructure of trigeminal ganglionSymptomsTemperatureTestingTherapeuticTouchTouch sensationTransmissionTraumaTrigeminal GangliasTrigeminal GanglionTrigeminal NerveTrigeminal SystemTrigeminal nerve structurealpha-Fucoseaxon signalingaxon-glial signalingaxonal signalingbiological signal transductioncell typecornea disordercornealcorneal wounddevelopmentaldry eyeeffective therapyeffective treatmenteye drynessgangliocyteganglion cellglia signalingglial signalingglycosylationimagingimprovedin situ Hybridization Geneticsin situ Hybridization Staining Methodin vivoinjuredinjuriesinnervationmacromoleculemalemodel of animalnerve cementnerve proteinnerve reconstructionnerve repairnerve signalingnerve supplynervous system regenerationneural regenerationneural signalingneuronalneuronal signalingneuropathicneuropathic painneuroregenerativeneurotransmissionnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachocular drynessocular painocular signs of drynessocular surfaceocular surface drynesspain signalpainful neuropathypathophysiologyperipheral nerve damageregenerateregenerated nervereinnervatereinnervationsNuc-Seqsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqtactile sensationtear deficiencytear productiontear secretiontransmission processtrigeminalvision lossvisual loss♀♂
Description preview
PROJECT SUMMARY/ABSTRACT
Corneal nerves are responsible for transmitting sensory information to the brain, providing feedback on touch,
pain, and temperature, and maintaining corneal health. Multiple studies have determined that corneal innervation
is commonly impaired in corneal disorders leading to opacities and eventual vision loss. The…
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