grant
Glycosphingolipids from the Soil Microbiome, Understanding Structure and Biosynthesis
Organization UNIVERSITY OF MISSISSIPPILocation UNIVERSITY, UNITED STATESPosted 15 May 2020Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AgonistAnabolismAnalytic ChemistryAnalytical ChemistryAntigensApplications GrantsArchitectureAreaAsialogangliosidesAssayBacteriaBacteroidesBioassayBioinformaticsBiological AssayBreathingCOBRECandidate Disease GeneCandidate GeneCell Communication and SignalingCell SignalingCenter of Biomedical Research ExcellenceCenters of Research ExcellenceChemistryComplexD-GalactoseDNA Molecular BiologyDataDevelopmentEngineering / ArchitectureEnzyme GeneEnzymesExposure toFloodingFloodsFormulationFutureGI microbiomeGalactopyranoseGalactopyranosideGalactoseGene ClusterGeneHomologGeneralized GrowthGenesGenomeGenomic DNAGenomicsGlycansGlycosphingolipidsGrant ProposalsGrowthHistoryHomologHomologous GeneHomologueHumanImmune signalingImmune systemImmunologic StimulationImmunological StimulationImmunostimulationIntracellular Communication and SignalingIonsKnock-outKnockoutKnowledgeLaboratoriesLibrariesLinkLipidsLiteratureMacrophageMapsMetabolic GlycosylationMicrobeMicrobiologyMiningModelingModern ManMolecularMolecular BiologyMonitorMφNanotechnologyNatural ProductsNatureNeutral GlycosphingolipidsOrganismOutcomes ResearchPathway interactionsPatternPolysaccharidesProcessProductionReceptor ProteinRecording of previous eventsReportingRespiratory AspirationRespiratory InspirationRoleSignal TransductionSignal Transduction SystemsSignalingSoilSourceSpeedSphingoglycolipidsSphingolipidsStructureStudentsSystemTailTechniquesTissue GrowthVaccine AdjuvantWorkalpha-GalCeralpha-galactosylceramidebiological signal transductionbiosynthesiscandidate identificationclinical relevanceclinically relevantcounterscreencytokinedesigndesigningdevelopmentaldigestive tract microbiomeenteric microbiomeentire genomefull genomegDNAgastrointestinal microbiomegenome sequencinggenomic datagenomic datasetglycosylationgut microbiomegut-associated microbiomehistorieshost microbiomeimmunogenimmunogenicimmunogenicityin vivoinspirationinterestintestinal biomeintestinal microbiomeknockout genelipidomicsliving systemmembermetabolism measurementmetabolomicsmetabonomicsmicrobiomemonomermutantnano porenano technano technologynano-technologicalnanoporenanotechnanotechnologicalnaturally occurring productnovelontogenypathwayreceptorscale upscreeningscreeningsserine C-palmitoyltransferaseserine palmitoyltransferaseskillssocial rolesugarwhole genomeα-GalCerα-galactosylceramide
Description preview
Project Summary
The production of the glycosphingolipid α-galactosylceramide (α-Gal) by a member of the human gut microbiome
was an intriguing discovery because these lipids are known to be immune stimulating antigens, and their
production by the gut microbiome suggests a role in host-microbiome signaling. α-Gal is the canonical agonist
for the…
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