grant
Glycomic Modulation of Inflammaging and Immune Functions during HIV Infection
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 15 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY20267S Gamma GlobulinAACTGACTGAIDS VirusAIDS clinical trial groupAb-dependent cellular cytotoxicityAccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAcylneuraminyl hydrolaseAgingAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntibodiesArchivesAttenuatedBindingBiological MarkersBloodBlood Reticuloendothelial SystemBody TissuesCancersCarbohydratesCardiac DiseasesCardiac DisordersCell BodyCellsCellular Immune FunctionChronicClinicalCommunicationD-GalactoseDNADataDeoxyribonucleic AcidDevelopmentDiagnosisExhibitsFDA approvedFaceFc ReceptorGalactopyranoseGalactopyranosideGalactoseGeneral PopulationGeneral PublicGlycansGlycoengineeringGoalsHIVHIV AntibodiesHIV InfectionsHIV SeronegativitiesHIV SeronegativityHIV individualsHIV infected individualsHIV infected personsHIV infection persistenceHIV interventionHIV negativeHIV peopleHIV persistenceHIV positive individualsHIV positive peopleHIV therapeuticHIV therapyHIV treatmentHIV viral infectionHIV viral persistenceHIV virus infectionHIV-1 infectionHIV-1 interventionHIV-1 persistenceHIV-1 therapeuticHIV-1 therapyHIV-1 treatmentHIV-Associated AntibodiesHTLV-III AntibodiesHTLV-III SeronegativitiesHTLV-III SeronegativityHTLV-III-LAV AntibodiesHealthHeart DiseasesHuman Immunodeficiency Virus therapyHuman Immunodeficiency Virus treatmentHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III AntibodiesIgGImmune systemImmunityImmunoglobulin GImpairmentInfection by HIV-1Infection from HIV-1Infection of HIV-1InflammagingInflammationInflammatoryInflammatory ResponseInterruptionIntestinalIntestinesLAV AntibodiesLAV-HTLV-IIILinkLymphadenopathy-Associated AntibodiesLymphadenopathy-Associated VirusLymphatic cellLymphocyteLymphocyticMalignant NeoplasmsMalignant TumorMediatingMolecular InteractionMyeloid CellsN-Acetylneuraminic AcidsN-Acylneuraminate GlycohydrolasesNatureNeuraminidaseOligosaccharide SialidaseOutcomePLWHPWHPolysaccharidesPrognostic MarkerPublicationsSamplingScientific PublicationSeveritiesSialic AcidsSialidaseStructureTestingTissuesViralVirusVirus-HIVacquired immunodeficiency syndrome clinical trial groupage associatedage correlatedage dependentage linkedage relatedage specificage-related inflammationaging associated inflammationameliorating inflammaginganti-inflammaginganti-viral immunityantibody dependent cell mediated cytotoxicityantibody dependent cytotoxicityantibody mediated cellular cytotoxicityantibody receptorantibody-dependent cell cytotoxicityantibody-dependent cellular cytotoxicityantibody-mediated cytotoxicityantiretroviral therapyantiretroviral treatmentantiviral immunityattenuateattenuate inflammagingattenuatesbio-markersbiologic markerbiomarkerbiomarker identificationbowelco-morbidco-morbiditycohortcomorbiditydevelopmentalexo alpha sialidasefacesfacialheart disorderhuman immunodeficiency virus infectionhuman immunodeficiency virus persistencehumanized micehumanized mouseidentification of biomarkersidentification of new biomarkersimmune functionin vivoindividuals infected with HIVindividuals with HIVindividuals with human immunodeficiency virusinfected with HIVinfected with human immunodeficiency virusinflamm-ageinginflamm-aginginflammaging mitigationinflammation associated with aginginhibitorinnate immune functionlymph cellmalignancymarker identificationmitigate age related inflammationneoplasm/cancernew approachesnovel approachesnovel strategiesnovel strategypeople infected with HIVpeople infected with human immunodeficiency viruspeople living with HIVpeople with HIVpeople with human immunodeficiency viruspersistent HIVpersistent HIV-1persistent human immunodeficiency viruspredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerpreservationpreventprevent age related inflammationprevent inflammagingpreventingpro-agingprogeronicprognostic biomarkerprognostic indicatorpromote agingreducing age related inflammationsenescencesenescentsialylationtreat HIVtreat Human Immunodeficiency Virusviral reboundvirus rebound
Description preview
PROJECT SUMMARY: There is an urgent need to identify biomarkers that can predict the development of
inflammation-associated comorbidities in people with HIV (PWH) on antiretroviral therapy (ART), as well as to
develop novel strategies to prevent or treat these comorbidities. Our recent data suggest that glycomic
alterations in circulating IgGs are…
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