grant
Glioma intelligence from behind enemy lines
Organization MAYO CLINIC ROCHESTERLocation ROCHESTER, UNITED STATESPosted 1 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY20262,5-Diaminopentanoic AcidAbscissionAddressAstrocytic GliomaAstrocytic NeoplasmAstrocytic TumorAstrocytomaAstrogliomaBBB disruptionBiochemicalBody TissuesBrainBrain CancerBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsCancersCathetersCell BodyCellsClinicalClinical EvaluationClinical ResearchClinical StudyClinical TestingClinical TrialsCombined Modality TherapyCystathionineDFMODL-alpha-DifluoromethylornithineDL-α-DifluoromethylornithineDataEflornithineEncephalonExcisionExperimental TherapiesExtirpationFeedbackGSSGGeneticGenomicsGlial Cell TumorsGlial NeoplasmGlial TumorGlioblastomaGliomaGlutathioneGlutathione DisulfideGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaHeterograftHeterologous TransplantationHumanImageImplantIn SituIntelligenceIntermediary MetabolismInvestigational TherapiesInvestigational TreatmentsKnowledgeL-Ornithine carboxy-lyaseLesionMALD-MSMALDIMALDI-MSMalignantMalignant - descriptorMalignant NeoplasmsMalignant TumorMalignant Tumor of the BrainMalignant neoplasm of brainMediatingMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMethionineMethionine MetabolismMethionine Metabolism PathwayMicrodialysisModelingModern ManMolecularMolecular WeightMonitorMultimodal TherapyMultimodal TreatmentNeuroglial NeoplasmNeuroglial TumorNeurological SurgeryNeurosurgical ProceduresOrnithineOrnithine Carboxy-lyaseOrnithine DecarboxylaseOrnithine Decarboxylase InhibitorOxidized GlutathionePathway interactionsPatientsPharmacodynamicsPhasePhase 0 StudyPhenotypePolyamine CompoundPolyaminesPre-Clinical ModelPreclinical ModelsRadiationRandomizedRecurrenceRecurrentRemovalReproducibilityResectedResistanceSafetySamplingSortingSourceSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationSpectroscopy, Mass, Matrix-Assisted Laser Desorption-IonizationStressStromal CellsSurgical RemovalTestingTherapeuticTherapeutically TargetableTimeTissuesTumor EscapeTumor Immune EscapeTumor TissueUpregulationXenograftXenograft procedureXenotransplantationalpha-Difluoromethyl Ornithinealpha-Difluoromethylornithineblood-brain barrier disruptionbloodbrain barrier disruptionbuild resiliencebuild resiliencycancer evasioncancer immune escapecancer immune evasionclinical relevanceclinical testclinically relevantcohortcombination therapycombined modality treatmentcombined treatmentdevelop resiliencedevelop resiliencydifluoromethylornithineenhance resilienceenhance resiliencyexperimental therapeutic agentsexperimental therapeuticsextracellularfacilitate resiliencegain of functiongamma-L-Glu-L-Cys-Glygamma-L-Glutamyl-L-Cysteinylglycineglial-derived tumorglioblastoma multiformeguanidinoacetatehuman dataimagingimprove resilienceimprove resiliencyimproved outcomeincrease resilienceincrease resiliencyloss of functionmalignancymatrix assisted laser desorption ionizationmetabolism measurementmetabolomemetabolomicsmetabonomemetabonomicsmulti-modal therapymulti-modal treatmentneoplasm/cancerneuroglia neoplasmneuroglia tumorneurosurgerynew approachesnovelnovel approachesnovel strategiesnovel strategypathwaypharmacologicpre-clinical studypreclinical studypromote resiliencepromote resiliencyrandomisationrandomizationrandomly assignedresearch clinical testingresectionresilienceresilience developmentresilientresistantspongioblastoma multiformestable isotopestandard of caresuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranslational progresstranslational progressiontumortumor evasiontumor immune evasiontumors in the brainuptakexeno-transplantxeno-transplantation
Description preview
Glioma intelligence from behind enemy lines
Molecularly diverse gliomas may leverage convergent metabolic survival pathways that can be therapeutically targetable. Microdialysis enables sampling of the extracellular microenvironment and represents a previously underutilized opportunity to characterize and pharmacodynamically monitor living human…
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