grant
Glial roles in experience-dependent critical period remodeling
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY202621+ years oldASDAdenosine Cyclic Monophosphate-Dependent Protein KinasesAdolescentAdolescent YouthAdultAdult HumanAfferent NeuronsAnimalsAssayAutismAutistic DisorderAutomobile DrivingBioassayBiological AssayBiosensorBrainBrain MappingBrain Nervous SystemCRISPRCRISPR/Cas systemCell BodyCell Communication and SignalingCell SignalingCellsClustered Regularly Interspaced Short Palindromic RepeatsCuesCyclic AMP-Dependent Protein KinasesDNA mutationDependenceDiseaseDisorderDoseDrosophilaDrosophila genusEarly Infantile AutismEncephalonEscalante syndromeExtracellular Signal-Regulated Kinase GeneFMR-1 ProteinFMR1 ProteinFMR1 geneFMRPFMRP proteinFRAXAFragile XFragile X Mental Retardation 1 GeneFragile X Mental Retardation ProteinFragile X SyndromeGene x Environment InteractionGeneticGenetic ChangeGenetic ModelsGenetic defectGenetic mutationGliaGlial CellsGxE interactionHeritabilityHumanImageImpairmentIndividualInfantile AutismInfiltrationIntellectual disabilityIntellectual functioning disabilityIntellectual limitationIntracellular Communication and SignalingKanner's SyndromeKinasesKnock-outKnockoutKolliker's reticulumLEOPARD SyndromeLabelLearningLifeLinkMAP Kinase GeneMAPKMapsMartin-Bell SyndromeMartin-Bell-Renpenning syndromeMediatingMemoryMessenger RNAMitogen-Activated Protein Kinase GeneModelingModern ManMolecularMultiple LentiginesMultiple Lentigines SyndromeMutateMutationNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeurogliaNeuroglial CellsNeuronal TransmissionNeuronsNeuropilNon-Receptor Type 11 Protein Tyrosine PhosphataseNon-neuronal cellNonneuronal cellNoonan SyndromeOdor Receptor ProteinOdorant Receptor ProteinsOdorant ReceptorsOlfactory Receptor ProteinsOutputPKAPTP-2 enzymePTP2CPTPN11PTPN11 genePathway interactionsPhagocytesPhagocytic CellPhagocytosisPhasePhosphatasesPhosphohydrolasesPhosphomonoesterasesPhosphoric Monoester HydrolasesPhosphotransferase GenePhosphotransferasesPositionPositioning AttributeProcessProtein Kinase AProtein Tyrosine Phosphatase 2CProtein-Tyrosine Phosphatase 2CProteinsRegulationRegulatory PathwayRenpenning syndrome 2ReporterResearchResolutionRoleSHP2SHP2 PhosphataseSHPTP2SensorySensory NeuronsShp-2 tyrosine phosphataseSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSynapsesSynapticSystemTestingTransgenic OrganismsTranslationsTransmission Electron MicroscopyTransphosphorylasesTurner phenotype with normal karyotypeTurner syndrome in female with X chromosomeTurner-like syndromeTyrosine Phosphatase SHP2Ullrich-Noonan syndromeVisualizationWorkX-linked mental deficiency-megalotestes syndromeX-linked mental retardation with fragile X syndromeX-linked mental retardation-fragile site 1 syndromeadulthoodamebocyteautism spectral disorderautism spectrum disorderautism-fragile X (AFRAX) syndromeautistic spectrum disorderaxon signalingaxon-glial signalingaxonal signalingbiological sensorbiological signal transductionbrain circuitrycAMP-Dependent Protein Kinasescritical perioddisease modeldisorder modeldrivingenvironment effect on geneexperiencefamilial Turner syndromefra(X) syndromefra(X)(28) syndromefra(X)(q27) syndromefra(X)(q27-28) syndromefragile X FMR1 proteinfragile X mental retardation 1fragile X mental retardation-1 proteinfragile X-mental retardation syndromefragile Xq syndromefragile site mental retardation 1fruit flygene environment interactiongene interactiongene manipulationgenetic manipulationgenetically manipulategenetically perturbgenome mutationglia signalingglial activationglial cell activationglial signalingimagingin vivointellectual and developmental disabilityjuvenilejuvenile humanknock-downknockdownlight microscopylimited intellectual functioningmRNAmacro-orchidism-marker X (MOMX) syndromemacro-orchidism-marker X syndromemale Turner syndromemar(X) syndromemarker X syndromemental retardation-macroorchidism syndromemutantnerve cementnerve signalingneural circuitneural circuitryneural signalingneurocircuitryneuronalneuronal circuitneuronal circuitryneuronal signalingneurotransmissionoptogeneticspathwayprogramsprotein expressionpseudo-Ullrich-Turner syndromerecruitresolutionssensory inputsocial rolesynapsesynaptic circuitsynaptic circuitrysynaptic pruningtime usetooltransgenictranslation
Description preview
Title: Glial roles in experience-dependent critical period remodeling
Summary
We propose glia actively prune brain circuits to optimize connectivity based on early-life sensory experience.
Drosophila approaches are used to identify molecular mechanisms of activity-dependent glial pruning restricted
to this short critical period. We propose these…
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