grant
Getting Excited about Cortical Malformations: Discovering the Mechanisms Leading to Seizure-prone Neurons in Malformations of Cortical Development
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 1 Jan 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY20250-11 years old3-D3-Dimensional3DAbscissionAffectAnimal ModelAnimal Models and Related StudiesAwardAxonBiologicalBourneville DiseaseBourneville PhakomatosisBourneville syndromeBourneville-Brissaud diseaseBourneville-Pringle syndromeBrainBrain Nervous SystemCalciumCell BodyCell Communication and SignalingCell SignalingCellsCementationChairmanChairpersonChairwomanChildChild YouthChildhoodChildren (0-21)Children's HospitalChronicClimactericClinicalColoradoCortical DysplasiaCortical MalformationDNA mutationDataDedicationsDefectDevelopmentDevelopment PlansDevelopmental DelayDevelopmental Delay DisordersDiseaseDisorderDysfunctionEEGElectroencephalogramElectroencephalographyElectrophysiologyElectrophysiology (science)ElectroporationEncephalonEpilepsyEpileptic SeizuresEpilepticsEpiloiaEquipmentExcisionExhibitsExtirpationFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2FrequenciesFunctional disorderFutureGeneralized GrowthGenerationsGenesGenetic ChangeGenetic defectGenetic mutationGoalsGrowthHumanImageIn VitroIndividualInterleukin ReceptorIntracellular Communication and SignalingIntractable EpilepsyInvestigatorsLabelLaboratoriesLaboratory PersonnelLeadLeadershipLengthLifeMechanistic Target of RapamycinMedicalMentorsMentorshipMiceMice MammalsModern ManMolecularMurineMusMutationNerve CellsNerve UnitNetwork AnalysisNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNeurosciencesNeurosurgeonOperative ProceduresOperative Surgical ProceduresPathway AnalysisPathway interactionsPatientsPb elementPediatric HospitalsPhotonsPhysiciansPhysiologyPhysiopathologyPre-Clinical ModelPreclinical ModelsPremature MortalityPringle diseaseProliferatingProteinsPyramidal CellsPyramidal neuronQualifyingRAFT1RefractoryRefractory epilepsyRemovalResearchResearch PersonnelResearch ResourcesResearchersResourcesRodentRodentiaRodents MammalsScientistSeizure DisorderSeizuresSignal TransductionSignal Transduction SystemsSignalingSliceSpecific Child Development DisordersSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSynapsesSynapticSynaptic plasticityTechniquesTestingTimeTissue GrowthTrainingTuberous SclerosisUpregulationViralWorkadenoma sebaceumaxonal degenerationbiocytinbiologicbiological signal transductionbiotinyl L lysinecareercareer developmentcerebral sclerosischildhood epilepsycomputational studiescomputer studiesdegenerative axondevelopmentaldrug-resistant epilepsyelectrophysiologicalelectroporative deliveryepilepsiaepileptogenicepiploiaexcitatory neuronexperienceexperimentexperimental researchexperimental studyexperimentsgain of function mutationgene electrotransfergenetic approachgenetic strategygenome mutationheavy metal Pbheavy metal leadhemimegalencephalyhereditary multiple system hamartomatosishippocampal pyramidal neuronhuman tissueimagingin uteroin vivoinhibitory neuronkidslab equipmentlaboratory equipmentlaboratory technologylife changemTORmalformation in cortical developmentmammalian target of rapamycinmethod developmentmodel of animalmouse modelmurine modelneural cell bodyneurinomatosis centralisneuro-surgeonneuromatosis universalisneuronalneuronal cell bodyneuronal growthneurospongioblastosis diffusaontogenypatch clamppathophysiologypathwaypediatricpediatric epilepsyphacomatosisprogramsreconstructionresectionsclerosis tuberosasomaspongioblastosis circumscriptasurgerysynapsetherapeutic targetthree dimensionaltuberose sclerosistuberous sclerosis complexyoungster
Description preview
Abstract
Background: Following surgical resection for intractable epilepsy caused by malformations of cortical
development (MCDs), over 30% of children continue to have life-changing seizures. Mutations in genes of the
mechanistic target of rapamycin (mTOR) pathway lead to these disorders that include focal cortical dysplasia
(FCD), tuberous…
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