grant
Geospatially modeled environmental risk factors for lymphoid malignancies
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 15 Jan 2024Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY202521+ years oldActive Follow-upAddressAdultAdult HumanAdult-Onset Diabetes MellitusAgeAir PollutantsApplication ContextAreaArsenicAutoimmune DiseasesB-Cell ActivationB-Cell CLLB-Cell Chronic Lymphocytic LeukemiaB-Cell Chronic Lymphogenous LeukemiaB-Cell Chronic Lymphoid LeukemiaB-Cell Lymphocytic LeukemiaB-Lymphocytic LeukemiaBMIBMI percentileBMI z-scoreBayesian MethodBayesian MethodologyBayesian Statistical MethodBayesian approachesBayesian classification methodBayesian classification procedureBayesian posterior distributionBenzeneBenzolBenzoleBiologic ModelsBiological ModelsBiometricsBiometryBiostatisticsBlood Plasma CellBody TissuesBody mass indexCLL Lymphoplasmacytoid LymphomaCadmiumCalendarCaliforniaCancer Prevention Study IICancersCausalityCd elementCellular Immune FunctionCessation of lifeChlorinated HydrocarbonsChronicChronic B-Lymphocytic LeukemiaChronic Lymphatic LeukemiaChronic Lymphoblastic LeukemiaChronic Lymphocytic LeukemiaChronic Lymphogenous LeukemiaCollaborationsConfounding Factors (Epidemiology)Confounding VariablesCox Proportional Hazards ModelsCyclohexatrieneDLBCLDataDeathDiagnosisDiffuse Large B-Cell LymphomaDioxin CompoundDioxinsDoseEcologic MonitoringEcological MonitoringEnvironmental EpidemiologyEnvironmental ExposureEnvironmental FactorEnvironmental MonitoringEnvironmental PollutantsEnvironmental Risk FactorEpidemiologic Confounding FactorEthnic OriginEthnicityEtiologyExposure toExposure to ultraviolet radiationFemale HealthFinancial HardshipFollow-Up StudiesFollowup StudiesGeneral PopulationGeneral PublicGeographic Information SystemsGerminoblastic SarcomaGerminoblastomaGrowth AgentsGrowth FactorGrowth SubstancesHealth Care ProfessionalHealth ProfessionalHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopathologyHematopoietic CancerHeterogeneityHistologicHistologicallyHistoryHumanImmuneImmune Cell ActivationImmune MarkersImmune PlasmaImmune systemImmunesImmunologic MarkersImmunomodulationIncidenceIndividualIndustrial WasteIndustrializationInflammationInfluentialsInfrastructureInvestigatorsJobsKetosis-Resistant Diabetes MellitusKnowledgeLife StyleLifestyleLymphocytic LymphomaLymphomaLymphoma, Lymphocytic, PlasmacytoidLymphoma, Lymphocytic, Well-DifferentiatedMalignant Hematologic NeoplasmMalignant LymphomaMalignant NeoplasmsMalignant TumorMalignant lymphoid neoplasmManuscriptsMature LymphocyteMaturity-Onset Diabetes MellitusMeasuresMedical HistoryMetalsMethodsModel SystemModelingModern ManModificationMultiple MyelomaNIDDMNeighborhoodsNon-Hodgkin's LymphomaNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNonhodgkins LymphomaNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNurses' Health StudyNutritionOccupationalOccupational ExposureOccupationsOrganochlorine CompoundsOrganochlorinesPCBsParticipantPathogenesisPathogenicityPatientsPersonal Medical HistoryPersonal Medical History EpidemiologyPersonsPesticidesPlasma CellsPlasma-Cell MyelomaPlasmacytesPollutionPolychlorinated BiphenylsPolychlorobiphenyl CompoundsPost-MenopausePost-menopausal PeriodPostmenopausal PeriodPostmenopausePredispositionPreventative strategyPrevention strategyPreventive strategyProfessional PositionsPropertyProspective StudiesProteins Growth FactorsPublic HealthPublishingQualifyingQuetelet indexRaceRacesRecording of previous eventsResearch PersonnelResearch ResourcesResearchersResidential MobilityResourcesReticulolymphosarcomaRiskRisk FactorsRoleSample SizeSlow-Onset Diabetes MellitusSmall B-Cell Lymphocytic LymphomaSmall Cell LymphomaSmall Lymphocytic LymphomaSmall-Cell LymphomaSmokingSolventsStable Diabetes MellitusSumSusceptibilityT2 DMT2DT2DMTimeTissuesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUV Radiation ExposureUV exposureUltraviolet Radiation Related ExposureUltraviolet radiation exposureUnited StatesWomanWomen's HealthWorkactivated B cellsactive followupadult onset diabetesadulthoodafter menopauseagesarsenicsautoimmune conditionautoimmune disorderautoimmunity diseaseblack femaleblack womencancer diagnosiscancer epidemiologycancer preventioncarcinogenicitycausationchlorohydrocarbonchronic lymphoid leukemiaclinical relevanceclinically relevantcohortcontextual factorsdesigndesigningdisease causationenvironmental contaminantenvironmental riskenvironmental testingexpression subtypesfinancial adversityfinancial burdenfinancial distressfinancial insecurityfinancial strainfinancial stressfollow upfollow-upfollowed upfollowing menopausefollowupgeospatial information systemhistoriesimmune activationimmune functionimmune modulationimmune regulationimmune-based biomarkersimmunologic reactivity controlimmunological biomarkersimmunological markersimmunomodulatoryimmunoregulationimmunoregulatoryindexingindustrial pollutantinsightketosis resistant diabeteslarge cell Diffuse non-Hodgkin's lymphomalymphoid cancerslymphoid malignancymalignancymaturity onset diabetesmenmodel organismmolecular sub-typesmolecular subsetsmolecular subtypesmyelomamyelomatosisneoplasm/cancernon-Hodgkins diseasenovelobese individualsobese peopleobese personobese populationobese subjectspast menopauseplasmocytepollutantpolychlorobiphenylpost-menopausalpostmenopausalpostmenopausal statusprospectiveracialracial backgroundracial originsexsocial rolesocio-demographic factorssocio-demographicssociodemographic factorssociodemographicsstudy populationteachertooltype 2 DMtype II DMtype two diabetesultraviolet exposureultraviolet light exposureunderstudied cancerworkplace exposure
Description preview
Project Summary/Abstract
Non-Hodgkin lymphoma (NHL) and multiple myeloma (MM) are cancers arising from mature lymphocytes that
collectively pose a substantial public health, personal and financial burden. Present knowledge of their
etiology is inadequate to inform prevention strategies; data from prospective studies, and for specific histologic…
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