grant
Genotoxicity and immunogenicity of the uropathogenic specific protein (USP) in the gut
Organization UNIVERSITY OF PUERTO RICO MED SCIENCESLocation SAN JUAN, UNITED STATESPosted 1 Apr 2024Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY202519S Gamma Globulin7S Gamma GlobulinAlimentary CanalAmino Acid SequenceAnti-Bacterial AgentsAntibodiesAntibody ResponseArchitectureAssayBacterial ToxinsBioassayBiological AssayBlood PlasmaBody TissuesC-terminalCaribbeanCaribbean Sea RegionCaribbean regionCell BodyCell DeathCell LineCell NucleusCellLineCellsCellular injuryClathrinColonColon or RectumColorectalColorectal NeoplasmsColorectal TumorsConfocal MicroscopyDNADNA DamageDNA InjuryDataData BasesDatabasesDeoxyribonucleic AcidDevelopmentDigestive TractDiseaseDisorderDysfunctionE coliE coli InfectionsE. coliE. coli InfectionsELISAEndothelial CellsEndotheliumEngineering / ArchitectureEnzyme-Linked Immunosorbent AssayEpithelial CellsEscherichia coliEscherichia coli InfectionsExplosionExposure toFecesFoundationsFunctional MetagenomicsFunctional disorderFutureGI TractGI microbiotaGamma-H2AXGastrointestinal DiseasesGastrointestinal TractGastrointestinal microbiotaGastrointestinal tract structureGene ProteinsGenesGoalsGut EpitheliumHealthHemalysinsHemolysinHospitalsHumanIRBIRBsIgGIgMImmunoblottingImmunoglobulin GImmunoglobulin MIncubatedInflammatory Bowel DiseasesInflammatory Bowel DisorderInstitutional Review BoardsIntestinalIntestinal DiseasesIntestinal DisorderIntestinesInvestigatorsJapanLabelLaboratoriesLarge Bowel TumorLarge Intestine NeoplasmLarge Intestine TumorMaintenanceMediatingMetagenomicsModern ManMonitorNeoplasmsNucleusOnset of illnessOrganoidsPathogenicityPatientsPeptide DomainPersonsPhosphorylationPhysiologicPhysiologicalPhysiologyPhysiopathologyPlasmaPlasma SerumPonsPons CerebelliPons VaroliiPontinePontine structurePopulationPrimary Protein StructureProtein DomainsProtein Gene ProductsProtein PhosphorylationProteinsPuerto RicoReceptor ProteinRecombinantsReportingResearch PersonnelResearchersReticuloendothelial System, Serum, PlasmaRisk AssessmentRisk FactorsRoleSamplingSerology testStrains Cell LinesStudentsTertiary Protein StructureTestingTissue EngineeringTissuesToxic effectToxicitiesToxinUmbilical CordUmbilical cord structureUrinary tractUrinary tract infectionUrinary tract infectious diseaseVeinsWest Indies RegionWestern BlottingWestern ImmunoblottingWomanWorkalimentary tractanti-bacterialbacteria in the gutbacteria pathogenbacterial pathogenbacteriocinbiobankbioengineered tissuebiorepositorybowelcatalystcell damagecell injurycellular damagecolon carcinogenesiscolorectal cancer registrycolorectal carcinogenesiscolorectal neoplasiacolorectumcultured cell linedamage to cellsdata basedevelopmentaldigestive canaldisease onsetdisease riskdisorder onsetdisorder riskengineered tissueenteric microbial communityenteric microbiotaenzyme linked immunoassayexperimentexperimental researchexperimental studyexperimentsfamilial colorectal cancerfecal samplegastrointestinal disordergastrointestinal epitheliumgastrointestinal microbial floragenotoxicitygut bacteriagut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microflorahereditary colorectal cancerhuman tissueimmunogenicimmunogenicityinflammatory disease of the intestineinflammatory disorder of the intestineinhibitorinjury to cellsinterestintestinal autoinflammationintestinal floraintestinal microbiotaintestinal microfloraintestinal tract microfloraintestine diseaseintestine disorderlarge bowel neoplasmmicrobialmutantnecrocytosisneoplasianeoplastic growthnovelnucleasepathogenic bacteriapathophysiologyprotein blottingprotein sequencereceptorresponseserology assaysocial rolestoolstool samplestool specimenurinary infectionγH2AX
Description preview
PI: Baerga-Ortiz, Abel
Title: Genotoxicity and immunogenicity of the uropathogenic specific protein (usp) in the gut
Project Summary
The uropathogenic specific protein (USP) is a multi-domain protein with nuclease activity
harbored by some uropathogenic strains of Escherichia coli. The protein has been shown to
cause damage to cultured endothelial…
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