grant
Genomic Instability and Cancer Genetics
Organization RUTGERS BIOMEDICAL AND HEALTH SCIENCESLocation Newark, UNITED STATESPosted 1 Mar 1997Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2025Antioncogene Protein p53AreaAutoregulationAwardBEK fibroblast growth factor receptorBEK protein tyrosine kinaseBRCA1BRCA1 Gene ProductBRCA1 ProteinBRCA1 geneBRCA2BRCA2 geneBasic ResearchBasic ScienceBiogenesisBody TissuesBreast Cancer 1 GeneBreast Cancer 1 Gene ProductBreast Cancer 2 GeneBreast Cancer Type 1 Susceptibility GeneBreast Cancer Type 1 Susceptibility ProteinBreast Cancer Type 2 Susceptibility GeneBreast-Ovarian Cancer ProteinCCSGCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCancer CenterCancer Center Support GrantCancer InterventionCancersCatchment AreaCell BodyCell CycleCell Cycle CheckpointCell Cycle ControlCell Cycle RegulationCell Division CycleCellsCellular Tumor Antigen P53Chromosome SegregationClassificationClinical TrialsCollaborationsCommunity OutreachDNA AlterationDNA DamageDNA Damage RepairDNA InjuryDNA RepairDNA Repair GeneDNA ReplicationDNA Sequence AlterationDNA SynthesisDNA biosynthesisDNA repair proteinDevelopmentEarly Onset Gene Breast Cancer 1Early Onset Gene Breast Cancer 2Early Onset Protein Breast Cancer 1EpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExposure toExpression SignatureFANCD1FGF-2 receptorFGFR-2Faculty RecruitmentFibroblast Growth Factor Receptor 2FundingGene ExpressionGene Expression ProfileGenesGeneticGenetic AlterationGenetic ResearchGenomeGenome InstabilityGenome StabilityGenomic InstabilityGenomic StabilityGenomic approachGenomicsGoalsGrantGrant ReviewHereditary Breast Cancer 1Hereditary Breast Cancer 2HomeostasisInstitutionInvestigationInvestigatorsJointsJournalsKnowledgeLeadershipMagazineMaintenanceMalignant NeoplasmsMalignant TumorMedicineMicro-tubuleMicrotubulesMitotic spindleMolecular Tumor SuppressionNCI-Designated Cancer CenterNational Institutes of HealthNeuroendocrine NeoplasmNeuroendocrine TumorsOncogenesisOncoprotein p53Origin of LifeP01 MechanismP01 ProgramP53PALB2PALB2 genePathway interactionsPeer ReviewPhosphoprotein P53Phosphoprotein pp53Physiological HomeostasisPilot ProjectsPrecision therapeuticsPredispositionProductivityProgram Project GrantProgram Research Project GrantsProtein TP53PublicationsQualifyingR-Series Research ProjectsR01 MechanismR01 ProgramRNF53Radiation OncologyResearchResearch GrantsResearch PersonnelResearch Program ProjectsResearch Project GrantsResearch ProjectsResearch SupportResearchersResource SharingRibosomesRisk FactorsRoleSchoolsScienceScientific PublicationScientistSecureSequence AlterationStrategic PlanningSubgroupSusceptibilitySystematicsSystems BiologyTOP1TOP1 geneTP53TP53 geneTRP53TechnologyTherapeuticTissuesTrainingTranslational ResearchTranslational ScienceTranslationsTumor Protein p53Tumor Protein p53 GeneTumor SuppressionUnderrepresented GroupsUnderrepresented PopulationsUnited States National Institutes of HealthUniversitiesUnscheduled DNA SynthesisValidationassociate facultyassociate professorbek fgf receptor kinasebek fibroblast growth factor receptor kinasebek-related fibroblast growth factor receptor-1brca 1 genebrca 2 genecancer cell genomecancer geneticscancer genomecancer progressioncancer riskcancer typecell cycle check pointchromosome divisionclinical investigationclinical translationclinically translatableclustered regularly interspaced short palindromic repeats screendevelopmentalepigeneticallygene expression patterngene expression signaturegene networkgenetic resourcegenomic alterationgenomic effortgenomic strategygenomic toolsimprovedindividualized cancer careindividualized oncologyinhibitorinnovateinnovationinnovativeinterdisciplinary approachmalignancymembermid-career facultymidcareer facultymultidisciplinary approachmutantneoplasm progressionneoplasm/cancerneoplastic progressionnovelp53 Antigenp53 Genesp53 Tumor Suppressorpartner and localizer of BRCA2pathwaypersonalized oncologypilot studypre-clinical researchprecision cancer careprecision cancer medicineprecision oncologyprecision therapiesprecision treatmentpreclinical researchpreventpreventingprofessorprogramsprotein p53recruitrecruit teachersreplication stresssingle cell analysissocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentteacher recruitmenttranscriptional profiletranscriptional signaturetranslationtranslation researchtranslational investigationtumortumor genometumor growthtumor progressiontumorigenesisunder representation of groupsunder represented groupsunder represented peopleunder represented populationsunderrepresentation of groupsunderrepresented peoplevalidationswork groupworking group
Description preview
GENOMIC INSTABILITY AND CANCER GENETICS PROGRAM
PROJECT SUMMARY/ABSTRACT
The overall goals of the Genomic Instability and Cancer Genetics (GICG) Program are to determine the
mechanisms by which genome stability is maintained to prevent tumorigenesis, to define the landscapes of
cancer genomes, and to expose the therapeutic vulnerability of cancer…
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