grant
Genomic Biomarkers of Cancer
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025CNS TumorCNS neoplasmCentral Nervous System NeoplasmsCentral Nervous System TumorsClassificationDNA AlterationDNA MethylationDNA Sequence AlterationDataGene ExpressionGenetic AlterationGoalsHistopathologyImageModelingMolecularOncologyOncology CancerPaperPatientsSequence AlterationSlideSystematicscancer biomarkerscancer markerscancer typedemographicsdigital pathologygenome wide methylationgenomewide methylationgenomic alterationgenomic biomarkergenomic markerglobal methylationimagingtumortumor diagnostictumor of the central nervous systemtumors in the central nervous system
Description preview
We have made substantial progress on goal #3, where we have submitted a paper to Lancet Oncology, showing that molecular genomic alterations can be predicted from histopathology in CNS tumors. Our model integrates three distinct components: the first classifies CNS tumors directly from slide images ('direct model'), the second initially generates…
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