grant
Genomic Ascertainment - Clinical and Behavioral Aspects
Organization NATIONAL HUMAN GENOME RESEARCH INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY2025AddressAmendmentAnxietyAreaAttitudeBehavioralBlood SampleBlood specimenClinicalClinical EvaluationClinical Medical SciencesClinical MedicineClinical TestingCollaborationsDataDevelopmentDiseaseDisorderDysfunctionFearFoundationsFrightFunctional disorderGene variantGenesGenetic CounselingGenetsGenomeGenomic TestingGenomic medicineGenomicsGenotypeGoalsHealthHealth Care CostsHealth CostsHealth Services EvaluationHealth Services ResearchImageIndividualInvestigatorsLaboratoriesMalignant HyperpyrexiaMalignant HyperthermiaMalignant hyperpyrexia due to anesthesiaMedicalMedical Care ResearchMedicineMental DepressionModelingMolecularMotivationMuscleMuscle TissueOverutilization of Health ServicesPaperParticipantPenetrancePersonsPharmacogeneticsPhenotypePhysiciansPhysiopathologyPopulationPredispositionPrevalenceRecommendationRecontactsRecurrenceRecurrentResearchResearch PersonnelResearch ResourcesResearchersResourcesRiskSightStandard ModelSurvey InstrumentSurveysSusceptibilityTest ResultTestingVariantVariationVisionWorkadverse consequenceadverse outcomeallelic variantanesthesia related hyperthermiabiobankbiorepositorycare resourcesclinical careclinical practiceclinical relevanceclinical testclinically relevantdata communicationdepressiondevelopmentaldiagnostic abilitydiagnostic capabilitydiagnostic powerdiagnostic utilitydiagnostic valueexomeexome sequencingexome-seqgenetic consultationgenetic counselorgenetic variantgenome based testinggenome medicinegenome scalegenome sequencinggenome testinggenome-widegenomewidegenomic DNA testinggenomic based testinggenomic clinical testinggenomic datagenomic datasetgenomic predictorsgenomic profiling testinggenomic screening testgenomic varianthealth care overutilizationhealth care resourceshyperthermia of anesthesiaimagingimprovedindividual patientinterestlow-frequency mutationmuscularneurosurgerynew technologynovel technologiesoveruse of health carepathophysiologyphenotypic dataprecision genomic medicineprogramsrare allelerare mutationrare variantreproductiveresearch clinical testingscreeningscreeningsservices researchtomographyvisual function
Description preview
Predictive genomic medicine or precision genomic medicine is of the highest medical importance and is an active area of research. We began piloting the return of genome-wide rare variants with the inception of the ClinSeq program in 2006, well before exome and genome sequencing became widespread (Biesecker et al., Genome Res 2009). We have…
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