grant
Genomic approaches to define hookworm population diversity and deworming drug response
NIHUS FederalResearch GrantFY20260-11 years oldAccelerationAddressAfricaAfrica South of the SaharaAfricanAlbendazoleAncylostomatidaeAnemiaAnimal ModelAnimal Models and Related StudiesAnthelminticsAntihelminthic AgentAntihelminthic DrugsAreaBioinformaticsChildChild YouthChildren (0-21)ChinaChromosomesCollaborationsCommunitiesCountryCricetinaeCross-Sectional StudiesCross-Sectional SurveyDALYDataDevelopmentDiagnosticDiseaseDisease Frequency SurveysDisorderDrug ExposureDrug resistanceDrugsEffectivenessEpidemiologic DeterminantsEpidemiologic FactorsEpidemiological FactorsEpidemiologyFarm AnimalFoundationsFutureGWA studyGWASGene ExpressionGenesGeneticGenomeGenomic approachGenomicsGeographyGhanaGoalsGold CoastHamstersHamsters MammalsHelminthsHookworm InfectionsHookwormsHost FactorHost Factor ProteinHumanIn VitroIndividualInfectionIntegration Host FactorsIntervention StrategiesInvestigatorsKnowledgeLMICLaboratoriesLaboratory StudyLivestockMainland ChinaMalnutritionMediatingMedicationMethodologyModelingModern ManMonitorMunicipalitiesNecator americanusNew World HookwormNutritional DeficiencyParasitesParasitic WormsPersonsPharmaceutical PreparationsPhenotypePlayPopulationPopulation HeterogeneityPredispositionPrevalencePublic HealthReportingResearchResearch PersonnelResearchersResistanceRiskRoleSoilStructureSub-Saharan AfricaSubsaharan AfricaSurvey InstrumentSurveysSusceptibilityTestingTimeTransmissionTreatment EffectivenessUndernutritionUniversitiesVaccinesVariantVariationVermifugesWidthWorld Health Organizationantihelminthicbenzimidazolecommunity spreadcommunity transmissioncommunity-level spreadcommunity-level transmissioncompanion animalcompanion petcross-sectional research studydata streamsdevelopmentaldietary deficiencydisability-adjusted life yearsdiverse populationsdrug efficacydrug resistantdrug/agenteggentire genomeepidemiologicepidemiologicalepidemiology research studyepidemiology studyepidemiology surveyfemale morbidityfield based datafield learningfield studyfield testfull genomegenome resourcegenome sequencinggenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic datagenomic data resourcegenomic datasetgenomic effortgenomic resourcegenomic sequencing resourcegenomic strategygenomic toolsheterogeneous populationimprovedkidslife year losslow and middle-income countriesmalnourishedmodel of animalmorbidity among femalesmorbidity among womenmorbidity in femalesmorbidity in womenmultidisciplinaryneglected tropical diseasesnovelnutrition deficiencynutrition deficiency disordernutritional deficiency disorderpopulation diversitypreservationprogramsreference assemblyreference genomeresistance to Drugresistantresistant to Drugresponseresponse to therapyresponse to treatmentscale upsocial rolesuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapy responsetransmission processtreatment responsetreatment responsivenesswhole genomewhole genome association analysiswhole genome association studywomen's morbidityyears of life lostyoungster
Description preview
PROJECT SUMMARY
Human hookworms infect approximately 500 million people worldwide and cause significant morbidity in women
and children residing in the tropics. The WHO has set ambitious goals to eliminate hookworm infection as a
public health problem by 2030. To meet these goals, mass drug administration (MDA) with benzimidazole
anthelmintics…
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