grant
Genome-wide CRISPRa screen to determine the antiviral repertoire of the cell
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025Anti-viral TherapyAttenuated VaccinesCRISPR activationCRISPR activatorCRISPR based activationCRISPR gene activationCRISPR transcription activationCRISPR transcriptional activationCRISPR-Cas-9-mediated gene activationCRISPR-based gene activationCRISPR-dCAS9 ActivatorCRISPR-mediated transcriptional activationCRISPR/CAS9 activationCRISPR/CAS9 gene activationCRISPR/dCas9 activationCRISPR/dCas9-based transcriptional activationCRISPRaCase Fatality RatesCell BodyCell Communication and SignalingCell DeathCell LineCell SignalingCell SurvivalCell ViabilityCellLineCellsDNA HelicasesDNA Unwinding ProteinsDNA unwinding enzymeDataEBOVEbola virusEbola-like VirusesEndogenous Interferon BetaFibroblast InterferonGene TranscriptionGenesGenetic TranscriptionGoalsGuide RNAHumanIFNIFN-βIFNbInfectionInterferon Type IInterferon-βInterferonsIntracellular Communication and SignalingLife CycleLife Cycle StagesLive-attenuated VaccineLiverMedicalMethodsMicrobeModern ManMolecularNatural Interferon BetaNatural human interferon betaOrganOrthoebolavirusProteinsPublic HealthRNA ExpressionRNA VirusesSignal TransductionSignal Transduction SystemsSignalingStrains Cell LinesTranscriptionTranscription InitiationTransmissionVaccine DesignViralViral DiseasesViral Gene ProductsViral Gene ProteinsViral GenesViral Hemorrhagic FeversViral ProteinsVirulenceVirusVirus DiseasesVirus ReplicationZinc Finger DomainZinc Finger MotifsZinc Fingersactivating CRISPR technologyanimal model developmentbiological signal transductioncell killingcompare to controlcomparison controlcultured cell lineemergent virusemerging virusgRNAgenome scalegenome wide screengenome-widegenomewidehelicasehemorrhagic feverhepatic body systemhepatic organ systemlife courselive vaccinelive vaccinesnecrocytosisnovelpromoterpromotortransmission processviral disease outbreakviral emergenceviral infectionviral infectious disease treatmentviral multiplicationviral outbreakviral replicationvirus disease outbreakvirus infectionvirus multiplicationvirus proteinvirus-induced disease
Description preview
The goal for this proposal is to functionally characterize restriction factors for emerging RNA viruses. As a starting point, we have focused on Ebola virus (EBOV). EBOV causes outbreaks of viral hemorrhagic fever in humans with a case-fatality rate as high as 60%. EBOV is a major public health concern because of its extreme virulence, its…
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