grant
Genome Engineering Core
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 8 Jul 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAreaBCAR1BCAR1 ProteinBCAR1 geneBehaviorBlood Precursor CellBreast Cancer Anti-Estrogen Resistance 1 ProteinBypassC-C CKR-5C-C CKR-5 GeneC-C Chemokine Receptor Type 5C-C Chemokine Receptor Type 5 GeneCC Chemokine Receptor 5CC-CKR-5CC-CKR-5 GeneCC-CKR5CCCKR5CCCKR5 GeneCCR-5CCR-5 GeneCCR5CCR5 ProteinCCR5 ReceptorsCCR5 geneCD195 AntigenCD195 Antigen GeneCHEMR13CHEMR13 GeneCKR-5CKR-5 GeneCKR5CKR5 GeneCKR5 ReceptorsCKRAS proteinCMKBR5CMKBR5 GeneCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCRK-Associated SubstrateCRKASCas nuclease technologyCas proteinCell BodyCell TherapyCellsChemokine (C-C Motif) Receptor 5Chemokine (C-C) Receptor 5Chemokine (C-C) Receptor 5 GeneChromosomal dislocationChromosomal translocationClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexCoupledDNADNA BindingDNA Binding InteractionDNA boundDNA mutationDataDeaminaseDeaminationDefectDeoxyribonucleic AcidDisablingDouble-Stranded DNAEndosomesEngineeringEnsureEnzyme GeneEnzymesGene InactivationGene ModifiedGene SilencingGene TranscriptionGenerationsGenesGenetic ChangeGenetic TranscriptionGenetic TranslocationGenetic defectGenetic mutationGenomeGenome engineeringGoalsGuide RNAHIVHIV-1 Fusion Co-ReceptorHIV-1 Fusion Co-Receptor GeneHematopoietic Progenitor CellsHematopoietic stem cellsHuman Immunodeficiency VirusesHyperactivityLAV-HTLV-IIILCM VirusesLCMVLentiviral VectorLentivirus VectorLocationLong-term infectionLymphadenopathy-Associated VirusLymphocytic choriomeningitis virusMediatingMethodsMissense MutationModelingModificationMolecularMonitorMutationNonsense MutationOutcomePenetrationPeptidesPositionPositioning AttributeProtein EngineeringProteinsRNA ExpressionRNA SplicingReceptor ProteinReceptosomesRecoveryRiskSiteSpecificitySplicingStructureSystemT-CellsT-LymphocyteTechnologyTimeToxic effectToxicitiesTranscriptionTransgenesViralVirusVirus-HIVWorkbase editingbase editorblood cell progenitorblood progenitorblood stem cellblood-forming stem cellcell based interventioncell engineeringcell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular engineeringcellular therapeuticcellular therapychromosome dislocationchromosome translocationchronic infectionds-DNAdsDNAengineered T cellsengineered immune systemexperiencegRNAgain of functiongene locusgene modificationgenetic locusgenetic protein engineeringgenetically engineered T-cellsgenetically modifiedgenome editinggenome mutationgenomic editinggenomic locationgenomic locusgenotoxicityhematopoietic progenitorhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellimmune engineeringimmunoengineeringindelinsertion/deletioninsertion/deletion mutationinsightintegration siteknockout genelentiviral integrationlentivirus integrationloss of functionmissense single nucleotide polymorphismmissense single nucleotide variantmissense variantmutantnon-sense mutationnovelnucleasep130 cas proteinp130CASpersistent infectionprotein designreceptorrepairrepairedtechnological innovationthymus derived lymphocytetranscriptional silencingtransgenetransgenic T- cellsvector
Description preview
Core B will provide expertise in genome engineering to support Projects 1,3, and 4 and Core C. Gene editing
has advanced tremendously in recent years, allowing targeted gene modification using CRISPR-Cas technology
and engineered base editors (BEs). Cas proteins, reprogrammable molecular scissors, create DNA breaks in an
RNA-guided manner, while…
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