grant
Genetics of novelty seeking and propensity for drug abuse in outbred rats
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Sept 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025ATAC sequencingATAC-seqATACseqAddictive BehaviorAddressAffectAmericanAmmon HornAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAnimalsAnxietyAreaAssayAssay for Transposase-Accessible Chromatin using sequencingBehaviorBehavioralBioassayBiological AssayBiologyBrainBrain Nervous SystemBrain regionBreedingCCRL2CCRL2 geneCKRXCRAM-ACRAM-BCandidate Disease GeneCandidate GeneCell BodyCell NucleusCellsCharacteristicsChemical DependenceChemokine (C-C Motif) Receptor-Like 2 GeneChromatinChronicCocaineCommon Rat StrainsCornu AmmonisCue-induced relapseDNADeoxyribonucleic AcidDiseaseDisorderDrug AddictionDrug DependenceDrug DependencyDrug ExperimentationDrug TherapyDrug abuseDrugsEmotionalEncephalonEnvironmentEnvironmental FactorEnvironmental Risk FactorEsthesiaExhibitsExpression SignatureFISH TechnicFISH TechniqueFISH analysisFISH assayFemaleFluorescence In Situ HybridizationFluorescent in Situ HybridizationFundingFutureGene Action RegulationGene ExpressionGene Expression ProfileGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGeneticGenetic TranscriptionGenomicsGenotypeGoalsHCRHeritabilityHigh-Throughput Nucleotide SequencingHigh-Throughput SequencingHippocampusHortega cellHumanImpulsivityIndividualIndividual DifferencesLearningLinkLocomotionMedicationMental DepressionMicrogliaModelingModern ManMolecularNerve CellsNerve UnitNeural CellNeurobiologyNeurocyteNeuronsNeurosciencesNucleusNucleus AccumbensPathway interactionsPersonality TraitsPersonalized medical approachPersonsPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhasePhenotypePlayPopulationPredispositionPsychosocial StressQTLQuantitative Trait LociRNA ExpressionRNA SeqRNA sequencingRNAseqRatRats MammalsRattusReactionRecommendationRegulationRelapseResearchRoleSelection CriteriaSensationShapesSocietiesSpecificitySprague-Dawley RatsStressSubstance Use DisorderSubstance abuse problemSusceptibilityTechniquesTechnologyTemperamentTextTranscriptTranscriptionTransposaseVariantVariationVulnerable Populationsabuse of drugsabuse of substancesabused drugabused drugsabuses drugsaddictionaddictive disorderanxious behaviorassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbrain metabolismcausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcell typeclinical relevanceclinically relevantcocaine seekingcocaine self-administrationdepressiondepressive behaviordrug abuseddrug interventiondrug of abusedrug seeking behaviordrug treatmentdrug/agentdrugs abuseddrugs of abuseentire genomeenvironmental riskepigenetic regulationexperiment with drugsfull genomegene expression patterngene expression signaturegenetic architecturegenetic selectiongenome scalegenome sequencinggenome-widegenomewidegitter cellhippocampalindividualized approachinsightlong read seqlong-read sequencinglong-read transcript sequencingmalemesogliamicroglial cellmicrogliocytemodel of animalmultiomicsmultiple omicsneuralneural circuitneural circuitryneural patterningneurobiologicalneurocircuitryneuronalnew technologynovelnovel technologiespanomicspathwayperivascular glial cellpersonalized approachpharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprecision approachprevent substance abusepsychostimulantpsychostimulant abusepsychostimulant useresponseself-administer cocainesocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstimulant abusestimulant usestress reactivitystructural mutationstructural variantstructural variationsubstance abusesubstance abuse controlsubstance abuse preventionsubstance use and disordersynaptic circuitsynaptic circuitrytailored approachtooltraittranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencinguse of stimulantsvulnerable groupvulnerable individualvulnerable peoplewhole genome♀♂
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Substance abuse disorders (SUDs) are a major challenge to individuals and society and are caused by the interplay between genetic factors that shape vulnerability to drug addiction and environmental variables that…
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