grant
Genetics and Immune Predictors for Recurrent Glomerular Diseases in the Kidney Allograft
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 1 Apr 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20257S Gamma GlobulinActive Follow-upAcuteAddressAllograftingAntibodiesBerger's DiseaseBiopsyBlood SerumCell Communication and SignalingCell SignalingClinical DataD-GalactoseDNADataDeoxyribonucleic AcidDevelopmentDiffuseDiseaseDisorderDonor ScreeningDonor SelectionEC 3.1.1.4EnsureExtramembranous GlomerulopathyFSGSFailureFc ReceptorFocal and Segmental GlomerulosclerosisFocal segmental glomerular sclerosisFutureGWA studyGWASGalactopyranoseGalactopyranosideGalactoseGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeneticGenetic ModelsGenetic PredispositionGenetic Predisposition to DiseaseGenetic RiskGenetic SusceptibilityGenetic propensityGenomicsGenotypeGlomerular diseaseGlycansGoalsHealthHereditaryIGA GlomerulonephritisIGA NephropathyIgA1IgGImmuneImmune MonitoringImmune TargetingImmune mediated therapyImmune signalingImmunesImmunoglobulin GImmunologic FactorsImmunologic MonitoringImmunological FactorsImmunological MonitoringImmunologically Directed TherapyImmunomonitoringImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapyIncidenceIndividualInheritedInherited PredispositionInherited SusceptibilityIntracellular Communication and SignalingInvestigatorsKidneyKidney DiseasesKidney FailureKidney GraftingKidney InsufficiencyKidney TransplantationKidney TransplantsKidney Urinary SystemLecithinase A2MediatingMembranous GlomerulonephritisMembranous GlomerulonephropathyMembranous GlomerulopathyMembranous NephropathyMicroanatomyMicroscopic AnatomyNIH RFANPHS1 gene productNephropathyPLA2PathogenesisPatient MonitoringPatientsPhospholipase A2PolysaccharidesPrognosisRecurrenceRecurrentRecurrent diseaseRegimenRelapsed DiseaseRenal DiseaseRenal FailureRenal Glomerular Diseases and SyndromesRenal GraftingRenal InsufficiencyRenal TransplantationRenal TransplantsRenal glomerular diseaseRenal glomerular disease or syndromeRenal glomerular disorderRenal glomerular syndromeRequest for ApplicationsResearchResearch PersonnelResearchersRiskRisk FactorsRisk-associated variantRoleSNP arraySNP chipSRINSSecondary toSerologySerumSignal TransductionSignal Transduction SystemsSignalingSteroid CompoundSteroid-resistant idiopathic nephrotic syndromeSteroidsTechnologyTestingTranscript Expression AnalysesTranscript Expression AnalysisTransplant RecipientsTransplantationTumor Necrosis Factor Superfamily LigandsUpregulationactive followupanalyze gene expressionantibody receptorbiological signal transductionclinical relevanceclinically relevantcohortdesigndesigningdevelopmentaldisease controldisorder controleffective therapyeffective treatmentfocal glomerulonephritisfollow upfollow-upfollowed upfollowupgene expression analysisgene expression assaygenetic etiologygenetic mechanism of diseasegenetic vulnerabilitygenetically predisposedgenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studyimmune suppressionimmune suppressive activityimmune suppressive functionimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunoglobulin A glomerulonephritisimmunoglobulin A nephropathyimmunologic substanceimmunological substanceimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedkidney allograftkidney disorderkidney txlecithinase Amembernanostringnephrinnovelphosphatidasephosphatidolipasephosphatidylcholine 2 acylhydrolasepost-transplantpost-transplantationposttransplantposttransplantationprecision medicineprecision-based medicinerenalrenal allograftrenal disorderrisk allelerisk generisk genotyperisk locirisk locusrisk variantsegmental glomerulonephritissingle nucleotide polymorphism arraysingle nucleotide polymorphism chipsocial rolesteroid-resistant nephrotic syndrometranscriptional profilingtranscriptome profilingtranscriptomic profilingtransplanttransplant centerstransplant patientwhole genome association analysiswhole genome association study
Description preview
PROJECT SUMMARY/ABSTRACT
The recent development of potent immunosuppressive regimens has led to decreased incidence of acute
rejection and increased incidence of non-rejection complications, including recurrent immune-mediated
glomerular diseases (GD) which have emerged as leading causes of kidney allograft failure.
IgA nephropathy (IgAN),…
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