grant
Genetically Dissecting Cholinergic Signaling in Body Weight Control
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 15 Jul 2016Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnimal Experimental UseAnimal ExperimentationAnimal ModelAnimal Models and Related StudiesAnimal ResearchAppetiteAutoregulationBehaviorBehavioralBody WeightBody Weight ChangesBrainBrain Nervous SystemBrain regionCNS Nervous SystemCancersCardiovascular DiseasesCause of DeathCell Communication and SignalingCell SignalingCentral Nervous SystemChronicDataDesire for foodDevelopmentDiabetes MellitusDiagonal Band of BrocaEatingEating BehaviorElectrophysiologyElectrophysiology (science)EncephalonExhibitsFeeding behaviorsFood IntakeFore-BrainForebrainFosteringGeneticGlutamatesGoalsHind BrainHomeostasisHumanHypertensionHypothalamic structureHypothalamusIndividualIngestive BehaviorIntermediary MetabolismIntracellular Communication and SignalingKnowledgeL-GlutamateMalignant NeoplasmsMalignant TumorMapsMediatingMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismModern ManMuscarinic Acetylcholine ReceptorMuscarinic ReceptorsNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeural PathwaysNeuraxisNeurocyteNeuronal TransmissionNeuronsNeurophysiology / ElectrophysiologyNicotinic Acetylcholine ReceptorsNicotinic ReceptorsNucleus AccumbensObesityObesity associated diseaseObesity related diseasePathway interactionsPhysiological HomeostasisPopulationProsencephalonRegulationResearchResistanceRhombencephalonRodentRodentiaRodents MammalsRoleSatiationSeriesSignal TransductionSignal Transduction SystemsSignalingSiteSmokingTestingThesaurismosisUnited StatesVascular Hypertensive DiseaseVascular Hypertensive DisorderWeight ChangeWeight GainWeight IncreaseWeight maintenance regimenadiposityamygdaloid nuclear complexanimal experimentationsaxon signalingaxon-glial signalingaxonal signalingbasal forebrainbiological signal transductionbody weight gainbody weight increasecardiovascular disordercease smokingcholinergiccholinergic neuroncorpulencedevelopmentaldiabetesdiet-associated obesitydiet-induced obesitydiet-related obesityeating cueselectrophysiologicalexperimentexperimental researchexperimental studyexperimentsfeedingfeeding-related behaviorsfood cuesglia signalingglial signalingglutamatergichigh blood pressurehindbrainhunger cueshyperpiesiahyperpiesishypertensive diseasehypertensive disorderhypothalamicin vivoinsightmalignancymetabolism disordermodel of animalneoplasm/cancernerve signalingneuralneural signalingneuronalneuronal signalingneurotransmissionnovelnutrient intake activitynutrient metabolismobesity developmentoptogeneticspathwaypreferenceprogramsquit smokingresistantresponsesatietysmoking cessationsocial rolestop smokingtherapeutically effectivetranscriptome profilingtranscriptomic profilingweight controlweight managementwt gain
Description preview
Abstract / Project Summary
Obesity-associated diseases such as diabetes and cardiovascular disease together account for the leading
cause of death in the United States. Roughly one-third of the U.S. population is obese, and it is estimated that
nearly half of the population will be obese within the next two decades. To date, studies investigating…
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