grant
Genetic studies of a pleiotropic transmembrane protease: insight from color variation in non-model organisms
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Jan 2024Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AcinonyxAdmixtureAffectAminopeptidaseAnimalsAreaAsianBiological FunctionBiological ProcessBlack PantherBody TissuesBreedingCandidate Disease GeneCandidate GeneCatsCats MammalsCell Communication and SignalingCell Culture TechniquesCell SignalingCharacteristicsCheetahsColorCommunitiesDNADNA mutationDarknessDeoxyribonucleic AcidDevelopmentDomestic AnimalsDomestic CatsEnteric Nervous SystemEsteroproteasesExhibitsExperimental GeneticsFamily FelidaeFelidaeFelidsFeline SpeciesFelis catusFelis domesticaFelis domesticusFelis sylvestris catusGWA studyGWASGene variantGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenetic studyHairHair ColorHeritabilityHumanHuman BiologyIndividualIntracellular Communication and SignalingInvestigationKO miceKnock-out MiceKnockout MiceLaboratory StudyLaboratory miceLeopardMammaliaMammalian CellMammalsMarbleMelanogenesisMembraneMiceMice MammalsModern ManMolecularMorphologyMurineMusMutant Strains MiceMutationNamesNull MouseOrganismPalatePanthera pardusPanthera tigrisPathway interactionsPatternPedigreePeptidasesPeptide HydrolasesPhenotypePigmentationPigmentation physiologic functionPlacenta BiologyPlacental BiologyPlacental DevelopmentPlacentationPopulationProtease GeneProteasesProteinasesProteolytic EnzymesProteomicsResearchRoleRuandaRwandaSamplingSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSkinSpottingsSystemTechnologyTestingTigersTissue SampleTissuesVariantVariationWNT Signaling PathwayWNT signalingWild AnimalsWorkZebraallelic variantbiological signal transductioncatscausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcell culturecell culturescell typedevelopmentaldiscover genesdomesticated animalentire genomeexperimentexperimental researchexperimental studyexperimentsfelinefetalforward geneticsfull genomegene discoverygene interactiongenetic approachgenetic associationgenetic pedigreegenetic resourcegenetic strategygenetic variantgenome mutationgenome sequencinggenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic varianthuman diseaseinhibitorinsightliving systemloss of functionmembrane structuremodel organismmouse geneticsmouse mutantnamenamednamingnovelpathwaypedigree structurepigmentationsself organizationsocial roletraittranscriptomicswhole genomewhole genome association analysiswhole genome association study
Description preview
Project Summary/Abstract
Mendelian variation in pigmentation is a rich genetic resource to identify and study signaling pathways relevant
to human biology, but the repertoire of mutations that affect pigmentation in mice and in humans coat color has
become saturated. Advances in genome sequencing technology now extend the reach of forward genetics…
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