grant
Genetic information flow in the Hallmarks of Aging: from system-level analytics to mechanistic interventions
Organization SPAULDING REHABILITATION HOSPITALLocation CHARLESTOWN, UNITED STATESPosted 20 Sept 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AffectAgeAgingAutomobile DrivingBackBasal Transcription FactorBasal transcription factor genesBindingBioinformaticsBiologicalBiological MarkersBody TissuesCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessCodeCoding SystemCollectionCommon Rat StrainsCommunicationComplexComputer AnalysisComputer SystemsDataDependenceDeteriorationDiseaseDisorderDorsumDysfunctionEntropyFeedbackFemaleFunctional disorderFutureGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGoalsHealthHumanImageImpairmentIndividualInfluentialsInformation TheoryInterventionInvestigationKnock-outKnockoutLifeLinkMaintenanceMapsMeasuresMethodologyMiceMice MammalsModelingModern ManMolecularMolecular Dynamics SimulationMolecular InteractionMurineMusMuscleMuscle FibersMuscle TissueMuscle functionMyotubesNatureNoiseOrganismOutcomePathologyPatternPhenotypePhysical FunctionPhysicsPhysiologicPhysiologicalPhysiopathologyPopulationProcessProgenitor CellsPropertyProteinsRNA SeqRNA sequencingRNAseqRatRats MammalsRattusRhabdomyocyteScienceSeriesSignal PathwaySkeletal FiberSkeletal MuscleSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesSubcellular ProcessSystemTestingTimeTissuesTranscription Factor Proto-OncogeneTranscription factor genesVoluntary MuscleWorkage associatedage associated effectsage correlatedage dependentage effectage linkedage relatedage related effectsage specificagedaged muscleagesaging effectaging of musclebio-markersbiologicbiologic markerbiological agebiomarkercomparativecomputational analysescomputational analysiscomputer analysescomputing systemdrivers of agingdrivingexperimentexperimental groupexperimental researchexperimental studyexperimentsgene manipulationgene networkgenetic informationgenetic manipulationgenetically manipulategenetically perturbgerodriverhallmarks of agingimagingimpact of agein vivoinfluence of ageinnovateinnovationinnovativelife spanlifespanliving systemloss of functionmalemid lifemid-lifemiddle agemiddle agedmidlifemolecular dynamicsmuscle agingmuscularnoveloperationoperationsoverexpressoverexpressionpathophysiologypillars of agingpreservationprogramsregeneration potentialregenerative potentialscRNA sequencingscRNA-seqsexshRNAshort hairpin RNAsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall hairpin RNAstem cellssuccesstooltranscription factortranscription regulatory networktranscriptome sequencingtranscriptomic sequencing♀♂
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ABSTRACT
Although aging is understood as a system-wide deterioration of cell and tissue function, it is nevertheless
associated with specific hallmarks, first introduced by López-Otín et al. in 2013. Because these hallmarks have
traditionally been studied in isolation, the relationships between them remain largely unknown, including
whether…
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