grant
Genetic heterogeneity and pleiotropy of neuroimaging and psychiatric phenotypes
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 20 Feb 2024Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY2026AdolescentAdolescent YouthAnatomic SitesAnatomic structuresAnatomyAtlasesBiologicalBrainBrain Nervous SystemBrain imagingBrain regionCerebral cortexChromosome MappingDataData CollectionDevelopmentDiagnosticDifferences between sexesDiffers between sexesDiseaseDisorderDosage CompensationDosage Compensation (Genetics)EncephalonEnhancersFaceFemaleFunctional RNAFutureGWA studyGWASGene LocalizationGene MappingGene Mapping GeneticsGene TargetingGene variantGenesGeneticGenetic HeterogeneityGenetic ModelsGenetic RiskGenomic SegmentGenotypeGoalsGonosomesHereditary DiseaseHumanImageInborn Genetic DiseasesIncidenceIndividualInherited disorderKnowledgeLinkLinkage MappingLiteratureMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMendelian randomizationMental disordersMental health disordersMethodologyMethodsModelingModern ManMolecularMorphologyNMR ImagingNMR TomographyNatureNeural DevelopmentNeurosesNeurotic DisordersNoncoding RNANontranslated RNANuclear Magnetic Resonance ImagingPathogenesisPathway interactionsPatternPhenotypePopulation GeneticsPrevalenceProcessPsychiatric DiseasePsychiatric DisorderPsychoneurosesQTLQuantitative Trait LociRiskSNP MapSample SizeSamplingScienceSex ChromosomesSex DifferencesSexual differencesSingle Base PolymorphismSingle Nucleotide PolymorphismSingle Nucleotide Polymorphism MapStructureSubgroupTestingTotal Human and Non-Human Gene MappingTwin Multiple BirthTwinsUntranslated RNAVariantVariationWorkX ChromosomeZeugmatographyallelic variantbiobankbiologicbiorepositorybrain MR imagingbrain MRIbrain magnetic resonance imagingbrain morphologybrain shapebrain visualizationcausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcerebral MR imagingcerebral MRIcerebral magnetic resonance imagingclinical phenotypecognitive developmentcohortcostdevelopmentalendophenotypeexomeexperimentexperimental researchexperimental studyexperimentsfacesfacialgene locusgene testinggene-based testinggenetic locusgenetic mappinggenetic testinggenetic variantgenome segmentgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic locationgenomic locusgenomic regiongenomic varianthereditary disorderheritable disorderimagingimprovedinborn errorinherited diseasesinherited genetic diseaseinherited genetic disorderinsightjuvenilejuvenile humanmalemental illnessneural imagingneuro-imagingneurodevelopmentneuroimagingneurological imagingneuropsychiatricneuropsychiatric diseaseneuropsychiatric disorderneuropsychiatryneuroticneuroticismnoncodingpathwaypleiotropic effectpleiotropismpleiotropypolygenetic risk scorespolygenic risk scorepsychiatric illnesspsychological disorderresearch studysexsex based differencessex-dependent differencessex-related differencessex-specific differencessingle nucleotide variantstructural mutationstructural variantstructural variationtherapeutic agent developmenttherapeutic developmenttherapeutic targettraitwhole genome association analysiswhole genome association study♀♂
Description preview
Project Summary
Our goal is to determine the connection among genes, brain structure and neuropsychiatric disorders. These
disorders are common and increasing in incidence worldwide. Lower costs of both genotyping and magnetic
resonance imaging (MRI) acquisition have provided an unprecedented opportunity to understand how genetic
factors shape…
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