grant
Genetic, Cellular and Molecular Mechanisms in Autoimmunity to Retina
Organization NATIONAL EYE INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY20252,3,7,8-Tetrachlorodibenzo-p-dioxin ReceptorsAH ReceptorsAI AugmentedAI assistedAI basedAI drivenAI enhancedAI integratedAI poweredATRAAccelerationAcuteAddressAdoptedAffectAgonistAnimal ModelAnimal Models and Related StudiesAntigen Presentation PathwayAntigen Processing and PresentationAntigen-Presenting CellsAntigensArtificial Intelligence enhancedAryl Hydrocarbon ReceptorAugmented by AIAugmented by the AIAugmented with AIAugmented with the AIAutoimmuneAutoimmune ResponsesAutoimmune StatusAutoimmunityAutomated Pattern RecognitionAutoregulationBioinformaticsBiologicalBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCNS autoimmunityCTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCell BodyCell Communication and SignalingCell SignalingCellsCharacteristicsChemotactic CytokinesChromosomesCollaborationsCorynebacteriumCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneDNA mutationData SetDioxin ReceptorsDiseaseDisease ProgressionDisorderEnsureEnvironmentEquilibriumExposure toEyeEyeballFOXP3FOXP3 geneFirmicutesForkhead Box P3GI microbiomeGI microbiotaGamma-delta T cellsGastrointestinal microbiotaGene x Environment InteractionGenerationsGenesGeneticGenetic ChangeGenetic defectGenetic mutationGliaGlial CellsGoalsGxE interactionHomeostasisHomologous Chemotactic CytokinesHumanIL-17IL-17 GeneIL-17AIL-17A GeneIL17IL17 ProteinIL17 geneIL17AIL17A GeneImmuneImmune mediated therapyImmune responseImmunesImmunityImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologically Directed TherapyImmunologicsImmunologyImmunomodulationImmunotherapyImpairmentIn VitroIndividualInfectionInfiltrationInflammasomeInflammationInflammatory ResponseIntercrinesInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin-17Intracellular Communication and SignalingJM2KI miceKnock-in MouseKolliker's reticulumLaboratoriesLevel of EvidenceLinkLipidsLymphatic cellLymphocyteLymphocyticManuscriptsMediatingMembraneMetabolicMiceMice MammalsMicrobeModelingModern ManModernizationMolecularMucosaMucosal Immune ResponsesMucosal TissueMucous MembraneMuller gliaMuller's cellMurineMusMutationMüller cellMüller gliaNIAIDNational Institute of Allergy and Infectious DiseaseNeurogliaNeuroglial CellsNon-neuronal cellNonneuronal cellNuclear TranslocatorOnset of illnessOrganismParentsPathogenicityPathway interactionsPatientsPattern RecognitionPhasePhysiological HomeostasisPolyaromatic Hydrocarbon ReceptorsPredispositionPreparationProcessProductionPropertyPseudomonas InfectionsReceptor ProteinRegulatory T-LymphocyteReportingResolutionRetinaRetinoic AcidRoleSCURFINSIS cytokinesScienceSeverity of illnessShapesShort-Chain Fatty AcidsSightSignal TransductionSignal Transduction SystemsSignalingSiteSupporting CellSusceptibilitySystemT cell responseT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT4 CellsT4 LymphocytesTCDD ReceptorsTIL4TLR2TLR2 geneTLR2 receptorTestingTherapeuticTissuesToll-Like Receptor 2Toll/Interleukin 1 Receptor-Like 4Toll/Interleukin 1 Receptor-Like 4 GeneToll/Interleukin 1 Receptor-Like Protein 4Trans Vitamin A AcidTregTrehaloseTretinoinTretinoinumUpregulationUveitisVisionVitamin AVitamin A AcidVolatile Fatty AcidsWorkaccessory cellall-trans-Retinoic Acidall-trans-Vitamin A acidarmartificial intelligence assistedartificial intelligence augmentedartificial intelligence basedartificial intelligence drivenartificial intelligence integratedartificial intelligence poweredautoimmune reactivityautoimmune uveitisautoreactive T cellautoreactivitybalancebalance functionbiologicbiological signal transductioncancer microenvironmentcentral nervous system autoimmunitychemoattractant cytokinechemokineclinical materialcostcytokinedata diversitydata explorationdigestive tract microbiomedisease onsetdisease severitydisorder onsetdiverse datadraining lymph nodeenhanced with AIenhanced with Artificial Intelligenceenteric microbial communityenteric microbiomeenteric microbiotaenvironment effect on genegain of function mutationgastrointestinal microbial floragastrointestinal microbiomegene environment interactiongenome mutationgenome resourcegenome scalegenome-widegenomewidegenomic data resourcegenomic resourcegenomic sequencing resourcegerm free conditiongut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomehigh dimensional datahost responsehuman diseasehuman florahuman microbial communitieshuman microbiotahuman microflorahuman-associated microbial communitieshuman-associated microbiotahumanized micehumanized mouseimmune modulationimmune regulationimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponsein vivoinsightintestinal biomeintestinal floraintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloraknockin micelens capsuleliving systemlymph cellmembrane structuremicrobial compositionmicrobiomemodel of animalmouse modelmulti-modalitymultidimensional datamultidimensional datasetsmultimodalitymultiomicsmultiple omicsmurine modelnerve cementocular surfacepanomicsparentpathobiontpathogenpathwaypreparationspreservationprogramsreceptorreconstitutereconstitutionregional lymph noderegulatory T-cellsresolutionsresponserestraintself-reactive T cellsingle cell analysissocial rolespecific pathogen freetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic agent developmenttherapeutic developmentthymus derived lymphocytetooltool developmenttrans-Retinoic Acidtranscriptomicstranslational studytumor microenvironmentvisual functionγδ T cellsγδT cells
Description preview
1) MMUNITY AND AUTOIMMUNITY OF THE NEURORETINA
The neuroretina is uniquely challenged to preserve vision while remaining protected from immune-mediated damage. Ocular immune privilege provides this balance, but the molecular basis of tolerance induction at the site of disease has remained poorly understood. We used single-cell transcriptomics to…
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