grant
Genetic and Molecular Mechanisms Connecting Mechanotransduction to Lipid Metabolism
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026AddressAssayAutomobile DrivingAutoregulationBioassayBiochemistryBiologicalBiological AssayBiological ChemistryBody TissuesC elegansC. elegansC.elegansCaenorhabditis elegansCalcium Ion SignalingCalcium SignalingCardiacCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular MechanotransductionCellular PhysiologyCellular ProcessCommunicationDNA mutationDefectDevelopmentDysfunctionEquilibriumFamilyFatty AcidsFoundationsFunctional disorderGenesGeneticGenetic ChangeGenetic ScreeningGenetic defectGenetic mutationGoalsHealthHomeostasisImpairmentIntracellular Communication and SignalingInvestigationIon ChannelIonic ChannelsKnowledgeLabelLinkLipidsLiverMechanical Signal TransductionMechanical StressMechanosensory TransductionMediatingMembrane ChannelsMetabolicModelingMolecularMutationOrganism-Level ProcessOrganismal ProcessOutcomePathogenicityPathologicPhysiologicPhysiologic ProcessesPhysiologicalPhysiological HomeostasisPhysiological ProcessesPhysiopathologyProcessProstaglandinsProstanoidsProteomicsRegulatory PathwayRegulatory ProteinResearchRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSkeletal MuscleStressSubcellular ProcessTherapeutic InterventionTissuesToxic effectToxicitiesVoluntary MuscleWorkadipogenesisbalancebalance functionbiologicbiological signal transductioncell behaviorcellular behaviordevelopmentaldrivingenergy balancefat metabolismgenetic regulatory proteingenome mutationhepatic body systemhepatic organ systeminsightintervention therapylipid biosynthesislipid metabolismlipogenesismechanical forcemechanosensingmechanotransductionnovelpathophysiologyregulatory gene productsocial roletooltranscriptomicstranslational applications
Description preview
Project Summary
Mechanotransduction and lipid metabolism are fundamental physiological processes essential for maintaining
cellular and tissue integrity. Mechanotransduction enables cells to sense and respond to mechanical forces,
driving tissue development, homeostasis, and adaptation. Lipid metabolism regulates lipid synthesis, storage,
and…
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