grant
Genetic and Molecular Dissection of Wnt Pathway Activation
NIHUS FederalResearch GrantFY2025APC - Adenomatous Polyposis ColiAPC ProteinAPC geneAPC genesAPC tumor suppressorAddressAdenomatosis Polyposis Coli GeneAdenomatous Polyposis ColiAdenomatous Polyposis Coli ProteinAnimalsAssayBeta Cadherin-Associated ProteinBeta-1 CateninBioassayBiochemicalBiologicalBiological AssayBody TissuesCK1CSNK1A1CSNK1A1 geneCUL-2CancersCell BodyCell Communication and SignalingCell SignalingCellsCollaborationsColorectal CancerCommunicationComplexCuesDP2.5DevelopmentDifferentiation and GrowthDiseaseDisorderDissectionDrosophilaDrosophila genusDrug TargetingExperimental DesignsFDA approvedGene TranscriptionGeneralized GrowthGeneticGenetic TranscriptionGoalsGrowthHLCDGP1Intracellular Communication and SignalingKinasesKnowledgeLaboratoriesMacromolecular Protein ComplexesMaintenanceMalignant NeoplasmsMalignant TumorMediatingModelingMolecularMultiprotein ComplexesNatural regenerationNuclearPARP HomologPRO2286PRO2975Pathway interactionsPhosphorylationPhosphotransferase GenePhosphotransferasesPredispositionProtein PhosphorylationProteomicsRNA ExpressionReceptor ProteinRegenerationRegulationResearchRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSpecific qualifier valueSpecifiedSusceptibilityTRF-1 Interacting, Ankyrin-Related, ADP-Ribose PolymerasesTRF1-Interacting Ankyrin-Related ADP-Ribose PolymeraseTankyraseTelomeric Poly-(ADP-Ribose)-PolymeraseTestingTissue GrowthTissuesTranscriptionTransphosphorylasesTumor Suppressor ProteinsWNT Signaling PathwayWNT signalingWorkbeta catbeta cateninbiologicbiological signal transductioncofactorcost effectivedevelopmentaldevelopmental diseasedevelopmental disorderdifferentiation factorsfruit flyimprovedin vivoinnovateinnovationinnovativemalignancymembrane activitymorphogenic factorsmorphogensneoplasm/cancernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenypathwayphospho-proteomicsphosphoproteomicsprogramsreceptorreconstitutereconstitutionregenerateregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissuesocial rolespatial and temporalspatial temporalspatiotemporaltherapeutic targettissue regenerationtissue regrowthtissue renewaltissue specific regenerationtooltumor suppressorβ-catenin
Description preview
PROJECT SUMMARY
Tissue specification, growth, maintenance, and regeneration rely on spatiotemporal cues provided by the
evolutionarily conserved Wnt morphogen pathway. Many developmental disorders and cancers, including
nearly all colorectal cancers, arise when the normal regulation of Wnt signal transduction is lost; yet key
mechanisms that…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click