grant
Genetic and hormonal mechanisms mediating sex differences in TB and TB-HIV
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Feb 2022Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026(TNF)-αAIDS VirusAbbreviationsAccess to CareAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdoptive TransferAdrenal GlandsAdrenalsAndrogenic AgentsAndrogenic CompoundsAndrogensAndrostenoloneAnimal ModelAnimal Models and Related StudiesAnimalsAntitubercular AgentsB cell growth factorB-Cell Differentiation Factor-1B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1BCDF-1BCGFBCGF-1BCSF 1BSF-1BSF1Basic ResearchBasic ScienceBinetrakinBiologic FactorBiologicalBiological FactorsBlood leukocyteBone MarrowBone Marrow Reticuloendothelial SystemCD154CD40LCD40LGCachectinCell BodyCell Communication and SignalingCell SignalingCellsCellular Immune FunctionCountryDHEADNA ContentDNA IndexDNA PloidyDehydroisoandrosteroneDifferences between sexesDiffers between sexesDisastersDisproportionate number of femalesDisproportionate number of menDisproportionate number of womenDisproportionately affects femalesDisproportionately affects womenDisproportionately impacts femalesDisproportionately impacts malesDisproportionately impacts womenDisproportionately in femalesDisproportionately in menDisproportionately in womenDoseEndocrine Gland SecretionEpidemicEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEstrogensEvaluationFOXP3FOXP3 geneFemaleForkhead Box P3Four Core GenotypesGender BiasGeneralized GrowthGenesGeneticGenotypeGonadal Steroid HormonesGonadal structureGonosomesGrowthHIVHIV InfectionsHIV individualsHIV infected individualsHIV infected personsHIV peopleHIV positive individualsHIV positive peopleHIV viral infectionHIV virus infectionHIV-1 infectionHIV/MtbHIV/TBHIV/mycobacterium tuberculosisHIV/tuberculosisHealth Services AccessibilityHormonalHormonesHourHumanHuman Immunodeficiency VirusesIFN-GammaIFN-gIFN-γIFNGIFNγIL-4IL4 ProteinImmuneImmune InterferonImmune responseImmunesImmunityImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunomodulationInfectionInfection by HIV-1Infection from HIV-1Infection of HIV-1Interferon GammaInterferon Type IIInterleukin-4Interleukin-4 PrecursorIntracellular Communication and SignalingInvestigatorsJM2KO miceKnock-out MiceKnockout MiceLAV-HTLV-IIILeukocytesLeukocytes Reticuloendothelial SystemLinkLymphadenopathy-Associated VirusLymphocyte Stimulatory Factor 1LyonizationM tbM tuberculosisM tuberculosis antigenM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis antigenM. tuberculosis infectionM. tuberculosis/HIVM.tb antigenM.tb infectionM.tuberculosis infectionMCGF-2MTB infectionMacrophageMacrophage ActivationMacrophage-Derived TNFMarrow leukocyteMast Cell Growth Factor-2MediatingMethodsMiceMice MammalsModelingModern ManMolecularMolecular AnalysisMonocyte-Derived TNFMtb antigenMurineMusMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis antigensMycobacterium tuberculosis infectionMφNecrotic LesionNull MouseObservational epidemiologyOutcomePBMCPLWHPWHPathogenesisPatientsPeripheral Blood Mononuclear CellPlayPloidiesPrasteroneProcessProcessed GenesProliferatingResearch PersonnelResearchersResistanceRiskRoleSCURFINSERMsSamplingSampling StudiesSelective Estrogen Receptor ModulatorsSeveritiesSex BiasSex ChromosomesSex DifferencesSex HormonesSex Steroid HormonesSexual differencesSignal TransductionSignal Transduction SystemsSignalingT cell responseT-Cell Growth Factor 2T-CellsT-LymphocyteTB infectionTB therapyTB treatmentTLR7TLR7 geneTLR8TLR8 geneTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFSF5TNFSF5 geneTNFαTRAP GeneTestosteroneTherapeutic AndrogenTherapeutic DehydroepiandrosteroneTherapeutic EstrogenTherapeutic TestosteroneTissue GrowthToll-Like Receptor 7Toll-Like Receptor 8Trans-TestosteroneTuberculosisTuberculostatic AgentsTumor Necrosis FactorTumor Necrosis Factor-alphaVirus-HIVWhite Blood CellsWhite CellWhole BloodX ChromosomeX InactivationX-Chromosome Inactivationaccess to health servicesaccess to servicesaccess to treatmentaccessibility to health servicesanti-TBanti-tuberculosisantiTBavailability of servicesbiologicbiological signal transductioncare accesschromosome complementcytokinedehydroepiandrosteronedesigndesigningdisproportionately affects malesdisproportionately affects mendisproportionately concentrated among mendisproportionately distributed among mendisproportionately higher among mendisproportionately impacts mendisproportionately occurs in mendisseminated TBdisseminated tuberculosisepigeneticallyfemale biasfemale predominancefemale preponderancegenetic analysisgonadgonadal steroidsgonadal surgeriesgonadectomygonadshealth service accesshealth services availabilityhost responsehuman femalehuman immunodeficiency virus infectionhuman maleimmune functionimmune modulationimmune regulationimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseindividuals infected with HIVindividuals with HIVindividuals with human immunodeficiency virusinfected with HIVinfected with human immunodeficiency virusinfection due to Mycobacterium tuberculosislFN-Gammamalemale biasmale predominancemen disproportionately diagnosedmen disproportionately experiencemen experience disproportionate ratesmodel of animalmouse modelmtbmultidisciplinarymurine modelneglectnovelontogenypeople infected with HIVpeople infected with human immunodeficiency viruspeople living with HIVpeople with HIVpeople with human immunodeficiency viruspharmacologicpredominance in femalespredominance in womenpredominantly affecting menresistantresponseservice availabilitysexsex based differencessex steroidsex-dependent differencessex-related differencessex-specific differencessocial rolesuprarenal glandsurgical removal of the gonadsthymus derived lymphocytetooltranscriptomicstreat M. tuberculosistreat Mtbtreat Mycobacterium tuberculosistreat tbtreat tuberculosistreatment accesstuberculosis infectiontuberculosis therapytuberculosis treatmenttuberculous spondyloarthropathywhite blood cellwhite blood corpusclewomen's predominancewomen's preponderance♀♂
Description preview
PROJECT SUMMARY
Tuberculosis (TB) occurs more frequently in males (~70% of cases) than females. While reduced access to care
for females and undercounting of female cases may contribute modestly to this longstanding epidemiologic
observation in some countries, both human studies (the Lűbeck disaster and eunuch studies) as well as animal
models…
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