grant

Genetic and biochemical dissection of mammalian pachytene piRNA biogenesis.

Organization MICHIGAN STATE UNIVERSITYLocation EAST LANSING, UNITED STATESPosted 9 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2026BiochemicalBiochemistryBiogenesisBiological ChemistryBiologyCannot achieve a pregnancyDataDevelopmentDifficulty conceivingDissectionFailureFecundabilityFecundityFertilityFertility DisordersFutureGametesGeneticGerm CellsGerm-Line CellsHumanInfertilityKnowledgeMale ContraceptionMale Contraceptive AgentsMale ContraceptivesMammaliaMammalsMeiosisMiceMice MammalsMitochondriaModern ManMolecularMurineMusNon-Polyadenylated RNAOrigin of LifePathway interactionsPopulationProductionProteinsPublishingRNARNA Gene ProductsReproductive CellsReproductive HealthRibonucleic AcidSex CellSmall RNASpermSpermatocytesSpermatogenesisSpermatozoaSpermiocytesSurfacedevelopmentalfertility cessationfertility defectfertility lossinfertileinitial cellinsightmale antifertility drugmale fertilitymale germ cellsmeioticmitochondrialmitochondrial membranemouse geneticsnovelpathwaypiRNApiwi RNAsexual cellsperm cellzoosperm
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PROJECT SUMMARY
Pachytene piRNAs are a population of PIWI-interacting RNAs unique to mammals that
are highly expressed in meiotic germ cells. Disruption in pachytene piRNA production
results in spermatogenic failure and infertility in both mice and humans. Pachytene
piRNAs are generated from long piRNA precursors through cleavage by a piRNA…

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Genetic and biochemical dissection of mammalian pachytene piRNA biogenesis. — MICHIGAN STATE UNIVERSITY | UNITED STATES | Dev Procure