grant
Genetic analysis of nematode cell differentiation
Organization COLUMBIA UNIV NEW YORK MORNINGSIDELocation NEW YORK, UNITED STATESPosted 14 Apr 2017Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AcetyltransferaseAddressAdhesionsAffectAxonal TransportAxoplasmic TransportBasal Transcription FactorBasal transcription factor genesBindingBiological FunctionBiological ProcessBody TissuesC elegansC. elegansC.elegansCaenorhabditis elegansCell BodyCell DifferentiationCell Differentiation processCell-Extracellular MatrixCellsChaperoneCholesterolCollectionCommunicating JunctionComplexCryo-electron MicroscopyCryoelectron MicroscopyDNA mutationDevelopmentDiseaseDisorderECMElectron CryomicroscopyExtracellular MatrixFutureGap JunctionsGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGeneticGenetic ChangeGenetic defectGenetic mutationGoalsGrantHSP-90HSP90HealthHeat-Shock Proteins 90HumanIndividualKnowledgeLow-resistance JunctionMacromolecular StructureMaintenanceMammaliaMammalsMechanicsMetabolic Protein DegradationModern ManMolecular ChaperonesMolecular InteractionMolecular StructureMutationNematodaNematodesNerve CellsNerve UnitNeural CellNeuritesNeurocyteNeuronal DifferentiationNeuronsNexus JunctionPersonsPhenotypeProcessProtein TurnoverPublic HealthReceptor ProteinRegulatory Protein DegradationResearchSpecific qualifier valueSpecifiedStructureSystemTissuesTouchTouch sensationTranscription Factor Proto-OncogeneTranscription RepressorTranscription factor genesTranscriptional RepressorTranslatingTranslational ResearchTranslational ScienceTubulinVisitWorkaxon growth cone guidanceaxon guidancebeta Tubulincellular differentiationcryo-EMcryoEMcryogenic electron microscopydevelopmentaldiscover genesexperimentexperimental researchexperimental studyexperimentsgene discoverygenetic analysisgenetic approachgenetic repressorgenetic strategygenome mutationhsp90 Familyinsightmechanicmechanicalmutantneuronalnovelpreventpreventingprotein degradationreceptorroundwormtactile sensationtooltranscription factortranslation researchtranslational investigationα Tubulinβ-Tubulin
Description preview
We will continue our study of genes needed for neuronal differentiation and
function using the six touch receptor neurons (TRNs) of the nematode Caenorhabditis
elegans. Our previous research identified genes needed for the generation,
specification, maintenance, and function of the TRNs. In the last grant period, we 1)
identified a “double…
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