grant
Genetic Analyses of Dendrite Morphogenesis in Caenorhabditis Elegans
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 1 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025ASDActinsAdhesion MoleculeAfferent NeuronsAgingAllelesAllelomorphsAnimalsAutismAutistic DisorderAxonBasal Transcription FactorBasal transcription factor genesBehaviorBinding ProteinsBinding SitesBiochemicalBiological FunctionBiological ProcessBipolar NeuronC elegansC. elegansC.elegansCaenorhabditis elegansCell Adhesion Molecule GeneCell Adhesion MoleculesCell BodyCell Communication and SignalingCell DeathCell FunctionCell PhysiologyCell ProcessCell SignalingCell Surface ReceptorsCellsCellular FunctionCellular MatrixCellular PhysiologyCellular ProcessCombining SiteComplexCytoskeletal SystemCytoskeletonDNA mutationDefectDendritesDevelopmentE2F Transcription Factor 1E2F transcription factor 1 proteinE2F transcription factorsE2F-1E2F-1 proteinE2F1E2F1 geneE2F1 proteinEarly Infantile AutismEnhancersEnsureEnvironmentEpidermisGTP PhosphohydrolasesGTPasesGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic ChangeGenetic ScreeningGenetic defectGenetic mutationGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesImageInfantile AutismIntracellular Communication and SignalingKanner's SyndromeLearningLigand Binding ProteinLigand Binding Protein GeneLinkMAP kinaseMapsMediatingMental RetardationMicro-tubuleMicrotubulesMitogen-Activated Protein KinasesModalityMolecularMorphogenesisMutationNematodaNematodesNerve CellsNerve UnitNeural CellNeural DevelopmentNeurocyteNeurodevelopmental DisorderNeurological Development DisorderNeuronsOrganismOutputPBR3PRB-Binding Protein E2F-1Pathway interactionsPatternPhenotypePostureProcessProprotein ConvertasesProtein BindingRBAP-1RBBP-3RBBP3RBP3Reactive SiteRegulatory ProteinResearchRetinoblastoma Binding Protein 3Retinoblastoma-Associated Protein 1SamplingSensorySensory NeuronsShapesSignal TransductionSignal Transduction SystemsSignalingSkinStimulusStructureSubcellular ProcessSuppressor MutationsSurfaceSynapsesSynapticTranscription Factor Proto-OncogeneTranscription factor genesTransmissionTreesWorkautism spectral disorderautism spectrum disorderautistic spectrum disorderaxon growth cone guidanceaxon guidancebiological signal transductionbound proteincell adhesion proteindesigndesigningdevelopmentalgenetic analysisgenetic approachgenetic regulatory proteingenetic strategygenome mutationguanosinetriphosphatasehuman diseaseimaginginsightintracellular skeletonliving systemloss of functionmodel organismmorphogenetic processmutantnecrocytosisneural circuitneural circuitryneurocircuitryneurodevelopmentneurodevelopmental diseaseneuronalneuropathologicneuropathologicalneuropathologyneuropsychiatric diseaseneuropsychiatric disordernovelpathwaypostmitoticprogramsreceptive fieldregulatory gene productroundwormsensory inputsomatosensorysynapsesynaptic circuitsynaptic circuitrytranscription factortranscription factor E2F1transmission process
Description preview
PI: Buelow, Hannes E.
Project Summary
Behavior in multicellular organisms is controlled by neural circuits in which neurons integrate
synaptic input and compute output. Most neurons are bipolar and comprise dendrites and axons,
which mediate reception and transmission of information, respectively. Dendrite branching is
necessary for correct…
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