grant
Generation and analysis of mouse models to define the roles of the ALS-associated factor Zfp106/ZNF106 in neurodegeneration
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Jan 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2025ALS patientsAddressAdolescentAdolescent YouthAffectAmyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseAmyotrophic Lateral Sclerosis patientsBindingBiochemicalCategoriesCell BodyCell Culture TechniquesCell NucleolusCellsDNA mutationDataDegenerative DisorderDegenerative Neurologic DisordersDiagnosisDiseaseDisorderG-QuadruplexG-Quadruplexes DNAG-Quartet StructuresG-QuartetsG-TetradsG4-DNAGehrig's DiseaseGenerationsGenesGeneticGenetic ChangeGenetic defectGenetic mutationHistopathologyHumanHuman ChromosomesKI miceKO miceKnock-inKnock-in MouseKnock-outKnock-out MiceKnockoutKnockout MiceLearningLou Gehrig DiseaseMaintenanceMapsMiceMice MammalsModelingModern ManMolecular InteractionMotor CellMotor Neuron DiseaseMotor NeuronsMurineMusMutationMyoneural JunctionNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuromuscular DiseasesNeuromuscular JunctionNeuron DegenerationNon-Polyadenylated RNANuclearNull MouseOrthologOrthologous GenePatientsPersonsPhenotypePlasmosomePlayPredispositionProteinsRNARNA BindingRNA Gene ProductsRNA ProcessingRNA SplicingRNA boundRNA metabolismRNA-Binding ProteinsRibonucleic AcidRoleSiteSkeletal MuscleSplicingSusceptibilityTestingUnited StatesVariantVariationVoluntary Musclecell culturecell culturescell typedegenerative conditiondegenerative diseasedegenerative diseases of motor and sensory neuronsdegenerative disorder of motor neuronsdegenerative neurological diseasesearly onsetfALSfallsfamilial ALSfamilial amyotrophic lateral sclerosisgenetic approachgenetic associationgenetic strategygenome mutationhuman diseasein vitro Assayin vivojuvenilejuvenile humanknockinknockin miceloss of functionmotoneuronmotor neuron degenerationmouse modelmurine modelmyoneural disorderneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurodegenerative phenotypeneurological degenerationneuromuscularneuromuscular degenerative disorderneuromuscular disorderneuronal degenerationneuroprotectionneuroprotectivenucleolusprotein functionsALSsocial rolesporadic ALSsporadic amyotrophic lateral sclerosisunpublished works
Description preview
Amyotrophic lateral sclerosis (ALS) and related motor neuron degenerative diseases affect more than 30,000
people in the US, and 90% of patients die within five years of diagnosis. Although ALS and ALS-like disease
manifestation varies, all forms are characterized by progressive loss of motor neurons. These disorders have a
strong genetic…
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