grant
Gene therapy methods for enhancing limb regeneration based on conserved transcriptional programs
NIHUS FederalResearch GrantFY202621+ years old3-D3-Dimensional3DAAV vectorAAV-based vectorAdeno-Associated VirusesAdultAdult HumanAmphibiaAmphibiansAmputationAnatomic SitesAnatomic structuresAnatomyAssayBasal Transcription FactorBasal transcription factor genesBioassayBiological AssayBody TissuesBone RegenerationBrachydanio rerioCapsidCaringCatalogsCell BodyCellsChromatinChromosomesComparative StudyComplexDNA TherapyDNA-Protein InteractionDanio rerioDependoparvovirusDependovirusDigitDigit structureDirected Molecular EvolutionDistalElementsEngineeringEnhancer ElementsEpidermisEventExhibitsExtremitiesFamilyGene ExpressionGene TranscriptionGene Transfer ClinicalGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGenetic Enhancer ElementGenetic InterventionGenetic TranscriptionGoalsGrowthHandHumanImmune PrecipitationImmunoprecipitationImpairmentIn vivo analysisInjuryKO miceKnock-out MiceKnockout MiceLimb structureLimbsMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMethodologyMethodsMiceMice MammalsModelingModern ManMolecularMolecular GeneticsMurineMusNamesNatural regenerationNon-TrunkNull MouseOrganismPathway interactionsPatientsPhalanxRNA ExpressionRegenerationRegenerative capacityRegulatory ElementReporterReportingSalamanderSamplingSerotypingSiteSpecificityTestingTissue GrowthTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationVariantVariationViralViral GenesVisualWorkZebra DanioZebra FishZebrafishadeno associated virus groupadeno-associated viral vectoradeno-associated virus vectoradulthoodappendageblastemabonecatalogcofactorconditional knock-outconditional knockoutdigit regenerationdirected evolutionenhancer sequencegene repair therapygene therapygene-based therapygenetic enhancer sequencegenetic therapygenomic therapyglobal gene expressionglobal transcription profilehandshealinghuman tissueimprovedin vivo evaluationin vivo testinginjuriesinsightintramembranous bonelimb losslimb regenerationliving systemlost limbmembernamenamednamingnovelontogenypathwayprogramspromoterpromotorregenerateregenerate boneregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueregeneration abilityregeneration capacityregeneration potentialregenerativeregenerative potentialselective expressionselectively expressedspatial and temporalspatial temporalspatiotemporalteleost fishteleostean fishteleostfishthree dimensionaltissue regenerationtissue regrowthtissue renewaltissue repairtissue specific regenerationtranscription factortranscriptomevector
Description preview
Abstract:
Adult teleost fish and urodele amphibians can regenerate entire amputated appendages, whereas this ability is
restricted to the tip of the distal phalanx in humans and mice. Though modest in comparison to its zebrafish and
salamander counterparts, mouse digit tip (MDT) regeneration exhibits similar anatomic stages and proceeds
with…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click